Guest Editors
Prof. Dr. Luigi Santacroce
Email: luigi.santacroce@uniba.it
Affiliation: Section of Microbiology and Virology, Interdisciplinary Department of Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy
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Research Interests: human microbiota, probiotics, nutraceuticals, essential oils, antimicrobials, microbiota-organs axes
Summary
The human microbiota is a complex ecosystem of billions of microorganisms that coexist with our body, influencing not only intestinal health and the immune system, but also various metabolic pathways, the onset and progression of tumors and even mental health. Furthermore, there are more and more studies demonstrating the ability of the resident microbiota to regulate the pharmacological response based on its composition.
A well-balanced microbiota (eubiotic) is certainly protective against the aggression of endogenous and exogenous factors, which can occur throughout life. On the contrary, conditions of dysbiosis can therefore be associated with various pathologies, in particular those typical of aging, assuming a fundamental role in the inflammaging process.
As our knowledge of the mechanisms underlying these host-microbiota interactions grows, we are seeing the emergence of new therapies that use microbiota modulation to treat various diseases, with an innovative approach that highlights the potential of personalized medicine, which takes into account the unique composition of each individual's microbiota to develop tailored diagnostic protocols and therapies.
In this light, the use of probiotics and synbiotics show an interesting role.
The aim of this special issue is to gather current knowledge on the human microbiota and its functional relationships with the human host, as well as to highlight and propose new theranostic applications of the microbiota in the perspective of precision medicine.
Keywords
human microbiota, probiotics, prebiotics, gut microbiota, uro-genital microbiota, microbiota and diseases, microbiota and health, microbial metabolome, microbiota and immune system
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