Guest Editors
Chen-Huan Yu, Chinese Academy of Sciences, Hangzhou, China. yuchenhuan2002@163.com
Meng Yang, University of California San Diego, San Diego, USA. yang_m21@yahoo.com
Jia-Qi He, Zhejiang Chinese Medical University, Hangzhou, China. hejiaqi7788@sina.com
Summary
Despite the continuous progress of science and technology, cancer remains one of the serious diseases threatening human life and health. Over the last decade, novel synthetic anticancer agents have not been succeeded as presumed in current clinical use. Cancer comprises a group of various diseases and involves uncontrolled multiplication and division of abnormal cells, which can form malignant growths and divert signaling pathways. Cancer cells lose many of the regulatory functions that non-cancerous cells exhibit and become susceptible to chemotherapeutic drugs that are not devoid of their intrinsic side effects. Toxicities such as myelotoxicity, cardiotoxicity, genotoxicity, pulmonary toxicity, cutaneous toxicity, and vasospastic are the major side-effects for common anticancer drugs such as 5-fluorouracil, doxorubicin, and bleomycin are well documented. There is, therefore, a need to develop new, effective, safer, and more affordable anticancer drugs from alternative sources.
Herbal active ingredients as a replacement for synthetic chemopreventive agents provide a potential for developing novel chemical entities to thwart cancer progression, many of which—such as vinblastine, vincristine, taxol, and camptothecin—have already been highlighted as having remarkable anticancer properties. There is also increasing evidence for herbal active ingredients' potential to act as inhibitors of various stages of tumorigenesis and associated inflammatory processes, underlining the importance of these products in cancer prevention. In addition to this, phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target locations with multiple scenarios/outcomes. Therefore, research into plant products may contribute to the development of effective and novel alternative therapeutics in the search for less toxic, eco-friendly, low-cost, fast, and cancer treatment drugs.
This Special Issue aims to collect original research and review articles regarding research into herbal active ingredients in cancer prevention.
Potential topics include but are not limited to the followings:
• Herbal active ingredients to prevent drug resistance in cancer chemotherapy
• Synergistic effects of herbal active ingredients and immunotherapy in cancer therapy
• The mechanisms of natural compounds targeting cancer stem cells
• Targeting non-coding RNA by herbal active ingredients for cancer therapy
• Prospects and paradigms of herbal active ingredients mediated cancer treatment
• Biomarkers targeted for plant-derived anticancer drug development
• Functional foods for suppressing cancer cells
• Proteomic profiles of herbal active ingredients in cancer treatment
Keywords
Traditional Chinese Medicine, Tumor Resistance, Synergistic Effects, Immunomodulation, Anti-Inflammatory Effects, Cancer Stem Cells, Tumor Microenvironment
Published Papers
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