Guest Editors
Dr. Elvira Grigorieva
Email: elv_grig@yahoo.com
Affiliation: Institute of Molecular Biology and Biophysics, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk 630117, Russia.
Homepage:
Research Interests: glycosylated macromolecules, tumor microenvironment, glioblastoma, molecular oncology, chemoradiotherapy, prognostic markers, molecular mechanisms
Summary
Glycosylated macromolecules play a pivotal role in cancer biology, influencing a wide array of cellular processes from signaling to adhesion. This special issue aims to explore the intricate interplay between glycosylation patterns and tumorigenesis.
By compiling cutting-edge research from global experts, this issue seeks to shed light on novel mechanisms and therapeutic opportunities in cancer research. Key areas of focus include but are not limited to:
1. Glycosylation Patterns in Cancer Development:
- Investigating how altered glycosylation patterns contribute to tumor initiation and progression.
- Understanding the role of glycosylated macromolecules in cellular adhesion, migration, and immune evasion.
2. Impact of Glycosylation on Tumor Microenvironment:
- Exploring how glycosylation influences interactions between tumor cells and their microenvironment.
- Examining the role of glycosylated proteins in modulating immune responses and promoting tumor growth.
3. Glycoproteins and Cancer Biomarkers:
- Identifying glycoproteins as potential biomarkers for cancer diagnosis, prognosis, and therapeutic targeting.
- Discussing the challenges and advancements in glycoproteomics for biomarker discovery.
4. Therapeutic Targeting of Glycosylated Macromolecules:
- Evaluating strategies to target glycosylation pathways for cancer therapy.
- Highlighting innovative approaches, including glycoengineering and glycosylation inhibitors, to disrupt oncogenic signaling.
5. Technological Innovations in Glycoscience:
- Advancements in glycomic and glycoproteomic profiling technologies.
- Development of novel tools for studying glycosylation dynamics in cancer cells and tissues.
Through this special issue, we aim to foster interdisciplinary collaboration and advance our understanding of how glycosylated macromolecules drive cancer biology. We welcome original research articles, comprehensive reviews, and perspectives that explore the multifaceted roles of glycosylation in cancer pathogenesis and therapy. By highlighting the latest discoveries and challenges in the field, this issue strives to pave the way for innovative therapeutic strategies and personalized medicine approaches in oncology.
Keywords
glycosylation, glycoproteins, proteoglycans, glycosaminoglycans, cancer biology, tumor microenvironment, biomarkers, therapeutic targeting
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