Guest Editors
Prof. Jun Yang
Email: junyang@utmb.edu
Affiliation: Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Homepage:
Research Interests: inflammation and innate immunity, neuroinflammation, epigenetics, antiviral response
Summary
Viruses employ sophisticated strategies to hijack host cellular mechanisms, manipulating processes such as the epigenome to facilitate their replication and survival. These interactions not only drive the viral life cycle but also contribute to disease pathogenesis, including tumorigenesis. This special issue, "Functional Interactions Between Viral Proteins and Cellular Mechanisms," aims to compile cutting-edge research from around the globe, shedding light on how viral proteins influence host cell functions and the resultant impact on disease development.
The issue will focus, but not be limited to, the following key areas:
1. Epigenetic Modifications Induced by Viral Infections:
Investigating the mechanisms through which viral infections alter DNA methylation, histone modifications, and chromatin remodeling.
Understanding the impact of these epigenetic changes on gene expression and cellular functions.
2. Viral Proteins and Host Epigenome Regulation:
Exploring the interactions between viral proteins and host epigenetic regulators.
Elucidating how these interactions affect chromatin state and gene expression profiles.
3. Role of Epigenetic Changes in Tumorigenesis:
Examining the contribution of virus-induced epigenetic modifications to cancer development.
Identifying potential biomarkers and therapeutic targets arising from these modifications.
4. Integrative Analysis of Virus-Host Interactions:
Combining gene-specific and genome-wide DNA methylation analyses with transcriptomic (RNA-seq) data to map the effects of viral infections.
Utilizing high-throughput sequencing and bioinformatics to uncover novel insights into virus-host dynamics.
5. Technological Advances in Epigenetic and Transcriptomic Studies:
Innovations in techniques for detecting and quantifying epigenetic changes and gene expression alterations.
Development of new tools and methodologies for studying the functional consequences of these modifications.
Keywords
viral-host interactions, epigenetic modifications, tumorigenesis, viral proteins, DNA methylation, chromatin remodeling, transcriptomic analysis, bioinformatics techniques
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