Special Issues
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Exosomes in Cell Communication and Disease: From Biomarkers to Therapeutic Targets

Submission Deadline: 31 August 2024 (closed) View: 209

Guest Editors

Natalia A. Osna, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, USA. nosna@unmc.edu

Zhijia Xia, Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians University, Germany. Zhijia.Xia@med.uni-muenchen.de

Summary

This special issue seeks to provide a comprehensive understanding of exosomes, their biogenesis, release pathways, content, and functions in various diseases, including cancer, cardiovascular diseases, obesity, sleep disorders, and neurodegenerative deficits. We have outlined the following key areas of focus:

 

Exosome Biogenesis, Release, and Content:

  • lInvestigate the mechanisms of exosome biogenesis and release pathways.

  • lExplore the diverse content of exosomes, including lipids, proteins, miRNAs, mRNAs, and other genetic materials.

 

Exosomes as Biomarkers:

  • Explore the potential of exosomes as diagnostic biomarkers in different diseases.

  • Discuss the specificity of exosomal cargos as indicators of disease onset and progression.

 

Immunosuppressive Exosomes in Disease Microenvironments:

  • Investigate the presence and heterogeneity of immunosuppressive exosomes in tumor and chronic inflammatory microenvironments.

  • Identify specific exosomal constituents responsible for immunosuppression.

 

Therapeutic Strategies Targeting Exosomes:

  • Assess the viability of targeting exosomes as a therapeutic intervention in diseases with immunosuppressive microenvironments.

  • Explore innovative strategies to modulate exosome release, uptake, or cargo content for therapeutic benefits.


Keywords

Exosomes; Cancer; Biogenesis; Biomarkers; Immunology

Published Papers


  • Open Access

    REVIEW

    Neural stem cell-derived exosomes: a cell-free transplant for potential cure of neurological diseases

    JIAJUN HUANG, WEI WANG, WENTONG LIN, HENGSEN CAI, ZHIHAN ZHU, WAQAS AHMED, QIANKUN ZHANG, JIALE LIU, YIFAN ZHANG, RONG LI, ZHINUO LI, AHSAN ALI KHAN, DENG LU, YONG HU, LUKUI CHEN
    BIOCELL, Vol.48, No.10, pp. 1405-1418, 2024, DOI:10.32604/biocell.2024.053148
    (This article belongs to the Special Issue: Exosomes in Cell Communication and Disease: From Biomarkers to Therapeutic Targets)
    Abstract Degeneration and death of nerve cells are inevitable with the occurrence and progression of nervous system disorders. Researchers transplanted neural stem cells into relevant areas, trying to solve the difficulty of neural cell loss by differentiating neural stem cells into various nerve cells. In recent years, however, studies have shown that transplanted neural stem cells help neural tissues regenerate and return to normal through paracrine action rather than just replacing cells. Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research More >

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