Guest Editors
Dr. Chiranjib Chakraborty, Adamas University, drchiranjib@yahoo.com
Professor Govindasamy Agoramoorthy, Tajen University, agoram@mail.nsysu.edu.tw
Summary
The discovery of the microRNAs (miRNAs) over two decades ago has led to the rapid evolution of scientific research focusing on this fascinating topic. Over 2,000 miRNAs have already been discovered so far in humans. They apparently regulate one third of the genes in the genome. The miRNAs have been implicated in numerous diseases affecting the humans. It has been reported that miRNAs regulate different diseases pathways through regulating various genes. It is also associated with the up and down regulation of different genes related to diverse diseases pathways. They play a distinct role to control the expression of different pathway proteins and thus they have a divergent regulatory role for emerging diseases.
In fact, the pathways of diseases can be regulated through the modulation of the different miRNA. On the other hand, several miRNAs have been modulated for therapeutic purposes we well. Some of the miRNA-based therapeutics is already undergoing preclinical and clinical trials. Similarly, they are being actively investigated as a potential clinical diagnostic. Circulating miRNAs can be used as a diseases marker for a range of diseases. Using miRNAs based biomarker, several next generation biomarkers can be developed and they could lead to rapid detection of different critical diseases. For all these intriguing reasons, we are organizing this special issue in BIOCELL to promote a series of high quality research papers emphasizing miRNAs functions, their associations and regulation mechanism to various diseases, next generation diagnostics and therapeutic potentials to deal the rapidly emerging human diseases in society. All the topics will be written by experts from these fields.
Potential topics to be covered in this special issue:
1. Regulatory Role of miRNAs in Heart Diseases
2. Regulatory Role of miRNAs in Brain Diseases
3. Regulatory Role of miRNAs in Bone Diseases
4. Regulatory Role of miRNAs in Liver Diseases
5. Regulatory Role of miRNAs in Different Types of Cancer
6. Different miRNA Based Therapeutics
7. Next Generation Diagnostics Development Using miRNA
Keywords
microRNA, Regulatory miRNA, Emerging Diseases, Therapeutics, Diagnostics
Published Papers
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