Table of Content

The aberrant signaling cascade transduction during disease development

Submission Deadline: 30 June 2023 Submit to Special Issue

Guest Editors

Prof. Dr. Tianjiao Wang, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China.

Prof. Dr. Jun Li, The Hong Kong University of Science and Technology Clear Water Bay, Kowloon, Hong Kong.

Prof. Dr. Yuhui Yuan, Institute of Cancer Stem Cell, Dalian Medical University, No. 9, West Section, Shunnan Rd., Shunkou District, Dalian City, Liaoning Province, China.

Prof. Dr. Zhiwen Hu, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China.


Abnormal activation and transduction of signaling pathways are observed in the initiation and development of various diseases. Iron channel alteration, phosphorylation, and ubiquitination of signal transducer factors trigger a series of downstream cascade reactions. Well-known signaling pathways, such as Wnt/β-catenin signaling, Notch signaling, Hedgehog signaling, MAPK/ERK signaling, PI3K/AKT, transforming growth factor β (TGF-β) signaling, and Hippo/YAP signaling, are frequently reported to be correlated with disease progression. These signaling pathways participate in the modulation of numerous cellular processes, including DNA repairment, inflammatory response, cellular stress, and metabolism, which consequently affect the development and pathological changes of tissues and organs. Recently, many novels signaling and pathways, such as m6A modification signaling, novel programmed cell death signaling, and novel post-translational modifications and histone modifications pathways were identified and widely investigated. The crosstalk of these novel signaling pathways with the classical signaling in the physiological and pathological processes is significant.

This Special Issue encourages studies indicating the exploration of cellular signaling transduction during disease development, as well as targeting the abnormal signaling pathways for the treatment of diseases using nanomaterials, traditional Chinese medicine, and western medicine. We welcome original research articles and review articles.


Potential topics include but are not limited to the following:

1. Modulation and crosstalk of signaling transduction in diseases

2. Bioinformatics for analyzing aberrant signaling transduction in diseases

3. Protein phosphorylation and ubiquitination in disease progression

4. The evaluation of traditional Chinese medicine against diseases based on the different signaling pathways

5. In silico studies of bioactive compounds against diseases

6. Synergistic effects of traditional Chinese medicine and western medicine against diseases

7. Delivery of Traditional Chinese medicine and western medicine using nanotechnology

8. Regulation mechanisms of cell signaling pathways in diseases

9. Statistical research of abnormal activation and transduction of signaling pathways

10. Reviews and Meta-analyses on the cell signaling transduction in diseases


aberrant signaling cascade transduction, metabolism remodeling, novel programmed cell death, traditional Chinese medicine and western medicine; nanomaterials

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