Special Issue "Cellular Biomechanics in Health and Diseases"

Submission Deadline: 31 March 2021 (closed)
Guest Editors

Dr. Ye Zeng, Sichuan University, ye@scu.edu.cn

Dr. Bingmei Fu, The City College of the City University of New York, fu@ccny.cuny.edu

Dr. Yongmin Yan, Jiangsu University, yym@ujs.edu.cn


Mechanotransduction has a crucial role for migration, adhesion, invasion, metastasis, angiogenesis and calcification, since it deals with the response of cells to physical forces such as shear stress, osmotic stress, substrate stiffness, and stretch. Signaling pathways such as autophagy, metabolism and exosomes are important to understand how physical cues transduce into cellular machinery to affect healthy and abnormal cells.

This topic focuses on the frontiers in cellular mechanics and the advances in cellular mechanism associated with physiological and pathological conditions.

We welcome biologists, physicists, and medical researchers to contribute original articles and reviews to this issue.

Mechanobiology, Cellular Metabolism, Epigenetics, Stem Cell, Vascular, Bone, Cancer

Published Papers
  • Benefit of prophylactic bronchodilator with β2 adrenergic agonist in ischemia-reperfusion-induced lung injury
  • Abstract Primary lung graft dysfunction could significantly attribute to ischemia-reperfusion lung injury (IRLI) during transplantation surgery. β2-adrenergic agonists were one of the bronchodilators that had been well-established in the management of asthma and chronic obstructive pulmonary disease (COPD) with anti-inflammatory potency. By applying the model of isolated rat lung, we evaluated the efficacy of short-acting β2-agonist inhalation to ameliorate ischemia-reperfusion damage. The experiment protocol was 180 min of global ischemia and then reperfusion for 60 min. In the β2-agonist inhalation group, aerosolized albuterol was administrated prior ischemia procedure. Increased weight ratios of wet to dry lung and microvascular permeability were characterized… More
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  • DTL facilitates the Fanconi anemia pathway for ultraviolet-induced DNA repair in retinal pigment epithelial cells
  • Abstract The excessive energy of light, especially the invisible rays with lower wavelength, is basically absorbed by retinal pigment epithelium (RPE) and usually causes DNA damage. The molecular mechanism behind DNA damage repair response to this frequent stress in RPE is not clearly understood. In this study, we determined that the Fanconi anemia (FA) pathway was activated in human RPE ARPE-19 cells after ultraviolet (UV) B and C treatment. Moreover, immunoprecipitation (IP) of FANCD2 indicated that denticleless E3 ubiquitin protein ligase homolog (DTL) closely interacted with FANCD2. Knockdown of DTL weakened the activity of the FA pathway in ARPE-19 cells responding… More
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  • Microfluidic chips for the endothelial biomechanics and mechanobiology of the vascular system
  • Abstract Endothelial cells arranged on the vessel lumen are constantly stimulated by blood flow, blood pressure and pressureinduced cyclic stretch. These stimuli are sensed through mechanical sensory structures and converted into a series of functional responses through mechanotransduction pathways. The process will eventually affect vascular health. Therefore, there has been an urgent need to establish in vitro endothelial biomechanics and mechanobiology of models, which reproduce three-dimensional structure vascular system. In recent years, the rapid development in microfluidic technology makes it possible to replicate the key structural and functionally biomechanical characteristics of vessels. Here, we summarized the progress of microfluidic chips used… More
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  • Three-month effects of corneal cross-linking on corneal fibroblasts
  • Abstract Corneal collagen crosslinking (CXL) has revolutionized the treatment of keratoconus in the past decade. In order to evaluate the 3-month effects of CXL on corneal fibroblasts, a longitudinal study at the tissue and cellular level was carried out with a total of 16 rabbits that underwent CXL, deepithelialization (DEP), or non-treatment (control) and kept for 1 to 3 months. The duration of corneal stromal remodeling after CXL was determined by examining the differentiation, apoptosis, and number changes of keratocytes in tissue sections from animals 1, 2, or 3 months post-treatment. Upon the finish of tissue remodeling, separate rabbits were used… More
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  • Application of photodynamic therapy in cancer: challenges and advancements
  • Abstract Although great achievements have been made in the past decades in medicine, cancer remains a worldwide public health issue. Surgery is usually accompanied by shortcomings such as residual lesions and poor treatment effects, and the successive appearance of other treatment methods, such as radiotherapy and chemotherapy, has not changed the postoperative recurrence rate, toxicity, and side effects. However, the advent of photodynamic therapy has greatly improved this situation. Photodynamic therapy is an emerging tumor diagnosis and treatment technology with good application prospects, photodynamic therapy uses a specific wavelength of light to excite a photosensitizer to generate reactive oxygen species, damage… More
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