Guest Editors
Prof. Valeria Magnelli
Email: valeria.magnelli@uniupo.it
Affiliation: Department of Science and Innovation Technology (DISIT), Università del Piemonte Orientale, 15121 Alessandria, Italy.
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Research Interests: microgravity, monocytes, patch-clamp, pfas, cell signaling
Prof. Maurizio Sabbatini
Email: maurizio.sabbatini@uniupo.it
Affiliation: Department of Science and Innovation Technology (DISIT), Università del Piemonte Orientale, 15121 Alessandria, Italy.
Homepage:
Research Interests: microgravity, monocytes, patch-clamp, pfas, cell signaling
Summary
Cell signaling is a cornerstone of biological processes, governing the behavior of normal and cancerous cells alike. The unique environment of microgravity offers a powerful platform tinvestigate these processes, shedding light on critical aspects of cancer biology such as metastasis and immune evasion. This special issue brings together cutting-edge research exploring the interplay between cell signaling regulation, microgravity-induced alterations, and cancer mechanisms, with the aim of uncovering novel therapeutic interventions.
Key areas of focus include but are not limited to:
1. Cell Signaling Dysregulation in Cancer
Understanding the roles of key signaling pathways (e.g., PI3K/AKT/mTOR, MAPK/ERK, TGF-β) in cancer progression.
Investigating therapeutic strategies targeting dysregulated signaling networks in tumors.
2. Impact of Microgravity on Cellular Mechanisms
Exploring how microgravity disrupts cytoskeletal organization, cell adhesion, and mechanotransduction.
Utilizing microgravity as a model tstudy tumor spheroid formation, metastatic potential, and drug response.
3. Cancer Immune Evasion Mechanisms
Deciphering molecular mechanisms such as PD-1/PD-L1 signaling and immunosuppressive microenvironments.
Studying the impact of microgravity on immune cell function and tumor immune evasion.
4. Therapeutic Approaches tCombat Metastasis and Immune Escape
Evaluating targeted therapies that disrupt the metastatic cascade and restore immune surveillance.
Translating microgravity-induced insights intinnovative cancer treatment paradigms.
5. Integration of Microgravity and Cancer Biology for Translational Impact
Leveraging findings from microgravity studies tmodel tumor progression and resistance mechanisms.
Bridging fundamental discoveries tclinical interventions in metastasis prevention and immune modulation.
This special issue invites original research articles, comprehensive reviews, and perspectives that delve intthe interconnected roles of cell signaling, microgravity, and cancer biology. By showcasing cutting-edge discoveries and highlighting emerging challenges, we aim tinspire new therapeutic avenues that tackle metastasis and immune evasion from a multidisciplinary perspective.
Keywords
cell signaling, microgravity, cancer biology, metastasis, immune evasion, therapeutic interventions, immune modulation, mechanotransduction, tumor microenvironment
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