Guest Editors
Assoc. Prof. Dr. Anton Tkachenko, BIOCEV, First Faculty of Medicine, Charles University, Prague,11636, Czech Republic.
Email: anton.tkachenko@lf1.cuni.cz
Dr. Volodymyr Yurievich Prokopiuk, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Department of Cryobichemistry, Kharkiv, Ukraine.
Email: v.yu.prokopiuk@gmail.com
Summary
Nanotechnology is a fast-growing branch of science that offers a growing number of diagnostic and therapeutic solutions in nanomedicine. Unique properties of nanoscale materials determined primarily by their size (1-100 nm) and high surface areas provide a wide range of nano-bio interactions. In particular, a growing body of evidence suggests that nanomaterials can modulate non-apoptotic regulated cell death (RCD) modalities, including necroptosis, pyroptosis, ferroptosis, autophagy-dependent cell death, etc. At the moment, the pharmaceutical modulation of these RCDs has been extensively studied for anti-cancer treatment.
Non-apoptotic RCDs can not only ensure cell death of cancer cells in malignancies resistant to apoptosis but also affect the tumor microenvironment regulating the immune landscape of tumors. However, the context-dependent behavior of RCDs and the requirement to trigger cell death fine-tuning the immune response to avoid triggering pro-carcinogenic inflammation are among the key challenges in the field.
This Special Issue will focus on the ability of different nanostructured materials to cause RCDs, elucidation of molecular mechanisms and possible cell death signaling-related targets to provide novel therapeutic avenues for anti-cancer treatment.
Keywords
cell death signaling, regulated cell death, apoptosis, ferroptosis, necroptosis, pyroptosis, autophagy
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