Guest Editors
Prof. Tang Zhu
Key Laboratory of Translational Tumor Medicine in Fujian Province, School of Basic Medical Science Putian University, China
Email: birdbsl500@gmail.com
Dr. Yidong Wang
The Second Affiliated Hospital of Medical College of Zhejiang University, China
Email: wangyidong@zju.edu.cn
Dr. Sadaruddin Chachar
Department of Biotechnology, Faculty of Crop Production Sindh Agriculture University, Pakistan
Email: schachar@sau.edu.pk
Summary
Cell signal is the core to control cell activity. Cells must adjust their own activities to adapte to the environment. These requirements are always changing, involving all of the process of growth and development, aging, disease resistance, etc. throughout life. These self-regulation responses of cells to meet the needs is to start the molecular target program of cell response through the receptor's perception of the environment and activation of signal pathways. Interestingly, the number of the receptors expressed by a single cell is far less than the amount of signal transduction by the different environments they respond to. That is, the number of intracellular signal pathways is very limited. In fact, although activation of different receptors leads to different cellular responses, they usually activate a set of highly overlapping pathways. In order to achieve the required large number of fine tuning response signals by the limited paths, the pathways are connected in a complex interconnection network. The changeable environmental stimuli are highly diversified, complex and dynamic. Cells must be able to calculate the finely adjusted output signals from these combined and changed input signals, which not only need to adjust individual cells, but also coordinate for group cell tissues. Recent technological developments, especially single cell analysis and kinetic quantification and manipulation, have enabled us to better understand the regulation and function of cell signals in controlling cell fate.
Challenges
Cells regulate the specific signal pathway intensity that may be output through the changes of ligand receptor binding configuration and concentration. Thus, using the limited number of the signaling proteins, the cells can fine-tune their responses against to numerous different external signaling. The feedback/forward loop and inter channel crosstalk lead to complex signal activity patterns. Although much progress has been made, our understanding of the precise transmission of cellular signals in health and disease, the crosstalk and combination of pathways, and how these signals encode specific fate changes is still limited. Signal transduction is the core regulator of cell fate selection, and comprehensive understanding also provides potential for developing drugs to improve therapeutic practices.
Aims of Special Issue
The establishment of this special issue will provide an academic communication platform for the cell signal transduction research, which will encourage more and more clinicians and basic researchers to participate in more in-depth exploration of the mechanism of cell signal transduction.
Proposal Topics
1. Cell functional signal transduction pathways, including but not limited to inflammation, cell death, cell proliferation, immune regulation and other signal pathways.
2. Cell signaling factors, including but not limited to NF-kB, JAK/STAT, AKT, p38, MEK, MAPK, WNT, PKA, AKAP, IKK, TAK, G proteins, calcium signaling, cAMP, GDP, GTP, etc.
3. Signal pathway regulative factor, includes small molecules or peptides.
4. Novel technical methods for signal transduction research.
5. Research on physiological and pathological signal pathways.
6. Drug development related to cell signaling pathway.
Keywords
cell signaling; cell; signal transduction; signal pathways
Published Papers
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