Guest Editors
Dr. Shaojie Jiang
School of Medical Imaging, Hangzhou Medical College, Hangzhou 310053, Zhejiang, China.
jsj1983@hmc.edu.cn
Summary
Nowadays, immunotherapy has profoundly changed the treatment mode in various cancers, including breast cancer. More clinical trials are ongoing since the first approval of atezolizumab by the FDA for the treatment of triple-negative breast cancer (TNBC) in 2019. These ongoing studies are evaluating combination strategies pairing immune checkpoint blockades (ICBs) with additional chemotherapeutic agents, small targeted molecules, monoclonal antibodies, and local ablative therapies to enhance response in both early-stage and metastatic disease. However, reliable predictive biomarkers of response to ICBs have not been established.
This topic aims to advance knowledge related to molecular features, immune cell profiles, regulatory mechanisms, and monitoring and assessment in breast cancer immunotherapy. We welcome authors to submit original research, review, and perspective articles focusing on, but not limited to, new findings in the following areas:
• Biomarkers (including genes, proteins, metabolites, etc.) that can be used to predict or improve response to ICBs in breast cancer immunotherapy.
• Alterations of immune cell profiles in breast cancer immunotherapy and their meanings to the immunotherapy process.
• Immune-related signaling pathways alterations of tumor-resident immunocytes and tumor cells in breast cancer immunotherapy and their meanings to the immunotherapy process.
• The mechanisms of progressive/hyper-progressive diseases in breast cancer immunotherapy.
• Communications among tumor-resident immunocytes, tumor cells, and stromal cells (or other types of cells) in tumor niche in breast cancer immunotherapy.
• The new strategies of treatment, monitoring, assessment, and management in breast cancer immunotherapy, such as artificial intelligence, mathematical model, and imaging evaluation, nanotechnology, proteolysis targeting chimeras (PROTAC) technology, and oncolytic virus therapy.
Keywords
Breast Cancer, Immunotherapy, Immune Checkpoint Blockades, Biomarkers, Immune Cell Profiles, Immune-Related Signaling Pathways, Progressive/Hyper-Progressive Diseases
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