Guest Editors
Dr. Farid Menaa, Department of Oncology and Nanomedicine, California Innovations Corp., USA. dr.fmenaa@gmail.com
Dr. Barkat A Khan, Faculty of Pharmacy, Gomal University, Pakistan. barki.gold@gmail.com
Summary
Stem cells (e.g. mesenchymal, “cancer stem cells”), mammalian biological molecules (e.g. genes, peptides, proteins, chemical or natural compounds) are emerging as complementary and alternative therapeutic solutions (e.g. gene and cell therapies) in the treatment of various health conditions. Inflammation, infections and superoxidation are largely involved in many pathological conditions, and conventional theranostic strategies are often limited in terms of safety and efficacy. Innovative polymer-based or nano-based formulations can modulate the cell behavior both morphologically and molecularly and can be a great alternative theranostic approach (e.g. tissue engineering, regenerative medicine). Screening (e.g. HTS, arrays) of drugs as well as the sequencing (e.g. NGS) of biologicals and pathological organisms are also crucial for enhancing the theranostics options (e.g. gene therapy).
This special issue focuses on physical characterizations, cellular, molecular, pharmacological, toxicological, and nanomedicinal aspects of biologicals, cells, chemical and natural compounds, that exert potential or confirmed theranostics activities (e.g. for therapeutic and/or diagnostic uses).
The effects of the biotheranostics agents and/or formulations may encompass anti-inflammatory, antioxidant, wound healing, anti-cancers, to anti-infectious activities (e.g. antibacterial, antifungal, antiparasitic and antiviral infections). Structure-function of the isolated biomolecules or cells with beneficial biological, immunological, pharmacological, and toxicological effects shall be highlighted by experimental (in vitro or ex-vivo) studies.
Researchers, industrials are kindly invited to submit their brightest review and/or research article for consideration in this Special Issue. Potential topics shall include but are not limited to:
● Human and animal pathologies
● Stem cells as theranostics
● Nanotheranostics and cellular effects
● Gene diagnosis and therapy
● Molecular and cellular pharmacology
● Phytotherapy
● Molecular screening and sequencing
● Signaling pathways
● Immunity and Inflammation
Keywords
Gene Therapy, Cell Therapy, Stem Cells, Biotherapeutics, Innovative Theranostic Formulations, Signaling Pathways, Inflammation, Oxydative Stress, DNA Damage, Phytopharmacology, Pharmacognosy, Molecular Docking, Regenerative Medicine
Published Papers
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Open Access
ARTICLE
Analysis of specific lipid metabolites in cord blood of patients with gestational diabetes mellitus
YANQIU LI, CHENJUN HAO, WEIYI CHEN, QINGJU MENG
BIOCELL, Vol.46, No.6, pp. 1565-1573, 2022, DOI:10.32604/biocell.2022.018347
（This article belongs to this Special Issue:
Biotherapeutic Agents and Innovative Theranostic Formulations: Physical-Chemical Aspects, Pharmacological and Biological Effects)
Abstract This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus (GDM), the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of GDM. From 2019–2020, 21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital, Panyu District, Guangzhou. The general information such as weight, height, age, body mass index (BMI) before pregnancy were analyzed. Non-targeted metabonomic detection and analysis were performed in umbilical cord plasma using LC-MS method. The age,…
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Open Access
ARTICLE
Synthesis and characterization of polymeric responsive CMC/Pectin hydrogel films loaded with Tamarix aphylla extract as potential wound dressings
BARKAT ALI KHAN, FAZAL KARIM, MUHAMMAD KHALID KHAN, FAHEEM HAIDER, SADIQULLAH KHAN
BIOCELL, Vol.45, No.5, pp. 1273-1285, 2021, DOI:10.32604/biocell.2021.015323
（This article belongs to this Special Issue:
Biotherapeutic Agents and Innovative Theranostic Formulations: Physical-Chemical Aspects, Pharmacological and Biological Effects)
Abstract The fourth most predominant overwhelming type of trauma is burn injuries worldwide. Ideal wound healing
dressings help in the wound healing process in a lower time with less pain. Commonly used dry wound dressing, like
absorbent gauze or absorbent cotton, possess limited therapeutic effects and require repeated use, which further
exaggerates patients’ suffering. In contrast, hydrogels films present a promising alternative to improve healing by
guaranteeing a moisture balance at the wound site. The aim of the current study was to synthesize
Tamarix aphylla
(
T. aphylla) extract-loaded hydrogel film with Na-CMC and pectin and to study their wound healing properties.…
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