Guest Editors
Dr. Quan Cheng
Department of Neurosurgery, Xiangya Hospital, Central South University, China
chengquan@csu.edu.cn
Dr. Hao Zhang
Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, China
zhsw@hospital.cqmu.edu.cn
Dr. Kui Zhang
The Pritzker School of Molecular Engineering, The University of Chicago, USA
Zhangk87@gmail.com; kuizhang@uchicago.edu
Dr. Nan Zhang
College of Life Science and Technology, Huazhong University of Science and Technology, China
awekevin@onethird-lab.com
Summary
Tumor-associated macrophages (TAMs), which comprise most of the immune cells infiltrating the tumor microenvironment (TME), are linked to poor prognosis, metastasis, and therapeutic resistance. Phenotypic plasticity enables them to adjust in response to the challenging tumor milieu and contributes to angiogenesis and lymphangiogenesis, malignant cell proliferation, inflammation, host cell immunosuppression, and therapeutic resistance. TAMs are also antineoplastic, particularly when exposed to drugs that enhance their phagocytic and oxidative actions. In preclinical and clinical investigations, TAMs-targeting techniques, such as TAM removal, phenotypic modification, and enhancement of TAMs' antigen presentation function, result in an anti-tumor innate immune response and have good synergy with other anti-cancer therapies. Numerous investigations have established a tight connection between macrophage polarization and TAM metabolism. New TAM targets for manipulating the TME to enhance therapy will be produced due to the high significance and interest of the molecular mechanisms underlying the metabolism of TAMs and the metabolic landscape throughout the progression of cancer and therapies.
The objective of this research topic is to gather thoughtful papers that discuss the development and future of immunity and metabolism in TAMs, to motivate scientists to continue studying tumor immuno-editing and to offer suggestions for using TAMs as targets for TME modulation to enhance clinical cancer therapy.
This Research Topic welcomes Original Research, Mini Reviews, Perspective, and Methods. The themes of this collection include but are not limited to the following areas:
• Molecular mechanisms underlying metabolic reprogramming of TAMs
• TAM metabolic landscape during cancer progression
• TAM metabolic reprogramming in response to anti-cancer therapies
• Macrophage-based diagnostic and immunotherapeutic approaches
• Novel biomarkers related to macrophages that can predict drug response
• Predictive models related to macrophages using computational approaches for optimizing the selection of treatment options.
Keywords
TAMs, TAM metabolism, Cancer therapy
Published Papers
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