Guest Editors
Prof. Dr. Dong Hwan Ho
Email: ethan2887@gmail.com
Affiliation: InAm Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-si 15865, Gyeonggi-do, Republic of Korea
Homepage:
Research Interests: Parkinson’s disease, Lewy body with dementia, parkinsonism, alpha-synuclein, leucin-rich repeat kinase 2, neuroinflammation, autophagy
Summary
Parkinson's disease (PD) and related parkinsonism disorders are characterized by complex cellular and molecular mechanisms, prominently involving LRRK2 mutations, neuroinflammation, and alpha-synuclein pathology. This special issue aims to explore the intricate molecular pathways driving these processes, with a focus on understanding the underlying mechanisms of neuronal dysfunction and degeneration in PD and related disorders.
By gathering cutting-edge research from global experts, this issue seeks to uncover novel insights into the roles of LRRK2, neuroinflammation, and alpha-synucleinopathy in neurodegeneration. Key areas of focus include, but are not limited to:
1. LRRK2 and Its Role in Parkinson's Disease Pathogenesis:
- Investigating the molecular mechanisms by which LRRK2 mutations contribute to the onset and progression of PD.
- Exploring the impact of LRRK2 on cellular processes such as mitochondrial function, autophagy, and protein degradation pathways.
2. Neuroinflammation in Parkinson's Disease and Alpha-Synucleinopathy:
- Understanding how chronic neuroinflammation contributes to neuronal degeneration in PD and related disorders.
- Investigating the interplay between microglia, astrocytes, and neurons in modulating neuroinflammatory responses.
3. Alpha-Synuclein Aggregation and Toxicity:
- Elucidating the molecular mechanisms underlying alpha-synuclein aggregation and its toxic effects on neurons.
- Exploring potential strategies to prevent or mitigate alpha-synuclein-induced neuronal damage.
4. LRRK2 in Neuroinflammation and Synucleinopathy:
- Investigating how LRRK2 modulates inflammatory pathways and contributes to the development of synucleinopathies.
- Understanding the crosstalk between LRRK2 signalling and alpha-synuclein pathology in neurodegenerative conditions.
5. Therapeutic Targeting of LRRK2 and Alpha-Synuclein:
- Evaluating novel therapeutic approaches to target LRRK2 and alpha-synuclein pathways for the treatment of PD and other synucleinopathies.
- Exploring the potential of anti-inflammatory therapies in modulating disease progression.
6. Emerging Biomarkers in Parkinson’s Disease and Synucleinopathies:
- Identifying novel biomarkers linked to LRRK2, neuroinflammation, and alpha-synuclein for early diagnosis and therapeutic intervention in PD.
- Discussing advancements in biofluid and imaging-based biomarker discovery.
Through this special issue, we aim to foster interdisciplinary collaboration and drive forward the understanding of how LRRK2, neuroinflammation, and alpha-synucleinopathy shape the pathology of Parkinson's disease and related disorders. We welcome original research articles, comprehensive reviews, and perspectives that delve into the molecular mechanisms underlying these key pathways in neurodegeneration. By highlighting the latest discoveries and challenges in the field, this issue seeks to pave the way for novel therapeutic strategies aimed at modifying disease progression.
Keywords
LRRK2, neuroinflammation, alpha-synucleinopathy, Parkinson’s disease, neuronal degeneration, autophagy, synucleinopathies, neurotoxicity, biomarkers, therapeutic targeting
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