Guest Editors
Prof. Dr. Suyun Lyu
Email: suyun@sunchon.ac.kr
Affiliation: College of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea.
Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
Homepage:
Research Interests: 3D cell culture, organoid, natural products, cancer, immunomodulation
Summary
Gaining insights into the dynamic interactions between cancer cells and the immune system is crucial for developing effective therapies. This special issue aims to explore the innovative use of 2D and 3D cell systems to unravel the complexities of cancer biology and immunology.
By bringing together pioneering research from global experts, this issue seeks to illuminate novel mechanisms and therapeutic avenues in cancer-immunology research. Key areas of focus include but are not limited to:
1. Mechanisms of Tumor-Immune Interactions:
- Investigating how cancer cells manipulate immune responses using 2D and 3D models.
- Understanding the role of tumor microenvironments in shaping immune cell behavior.
2. Advancements in Cell Model Technologies:
- Exploring the development and optimization of 3D cell culture systems for better mimicking in vivo conditions.
- Evaluating the impact of mechanical and biochemical cues on cancer-immune cell interactions.
3. Therapeutic Development Using Cell Models:
- Identifying novel therapeutic targets through innovative use of cell systems.
- Discussing the potential of 2D and 3D models in preclinical drug testing and validation.
4. Immune Evasion Strategies of Tumors:
- Examining how different cell models can reveal mechanisms of immune evasion in various cancer types.
- Understanding the impact of tumor heterogeneity on immune response.
5. Future Directions in Cancer-Immunology Research:
- Highlighting interdisciplinary approaches that integrate engineering and immunology with cancer biology.
- Discussing the implications of emerging technologies, such as organoids and microfluidics, for advancing research.
Through this special issue, we aim to foster collaborative efforts and enhance our understanding of cancer-immunology dynamics. We welcome original research articles, reviews, and perspectives that delve into the multifaceted roles of 2D and 3D cell models in elucidating these complex interactions. By showcasing the latest findings and ongoing challenges, this issue strives to pave the way for innovative therapeutic strategies in oncology.
Keywords
2D cell systems, 3D cell models, cancer biology, immunology, tumor microenvironment, therapeutic development, immune evasion
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