Submit

Login Login

Register Register

Home / Journals / BIOCELL / Online First / doi:10.32604/biocell.2024.056981
Journal Menu
Special Issues
Table of Content

All issues

Online First

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

SAIB Annual Meetings

Open Access

REVIEW

Macrophage polarization in cardiac transplantation: Insights into immune modulation and therapeutic approaches

JINGWEI JIANG1,2, BO JIA3, CHUAN WANG3, CHEN FANG1, YUGUI LI1, GUOXING LING1, BAOSHI ZHENG1,*, CHENG LUO1,*
1 Department of Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China
2 The First Clinical Medical College of Guangxi Medical University, Nanning, 530021, China
3 Department of Cardiovascular Surgery, Beijing Anzhen Hospital of Capital Medical University, Beijing, 100029, China
* Corresponding Author: BAOSHI ZHENG. Email: email; CHENG LUO. Email: email
(This article belongs to the Special Issue: Exploring Mitochondria: Unraveling Structure, Function, and Implications in Health and Disease)

BIOCELL https://doi.org/10.32604/biocell.2024.056981

Received 04 August 2024; Accepted 31 October 2024; Published online 02 January 2025

Abstract

The role and regulatory mechanisms of macrophage polarization in cardiac transplantation have gained significant attention. Macrophages can polarize into either the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype in response to environmental cues. M1 macrophages facilitate transplant rejection by releasing inflammatory mediators and activating T cells, whereas M2 macrophages support graft survival by secreting anti-inflammatory factors and promoting tissue repair. Mitochondrial quality control regulation plays a crucial role in macrophage polarization, which may influence graft survival and immune responses. This review provides an overview of the current understanding of mitochondrial quality control-regulated macrophage polarization in cardiac transplantation, its effects on graft outcomes, and potential therapeutic strategies to modulate this process to enhance transplant success rates. The review was conducted by systematically analyzing recent studies and integrating findings from key research articles to synthesize a comprehensive understanding of this emerging field.

Keywords

Cardiac transplantation; Mitochondrial quality control; Macrophage polarization; immune tolerance; transplant rejection

  • 125

    View

  • 40

    Download

  • 1

    Like

Related articles
Copyright© 2025 Tech Science Press
© 1997-2025 TSP (Henderson, USA) unless otherwise stated

Share Link