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REVIEW

The diverse functions and therapeutic implications of cancer-associated fibroblasts in colorectal cancer

ZEYIN LAI1, HANGYUAN ZHAO1, HONG DENG1,2,*
1 Department of Pathology, Key Laboratory of Disease Proteomics of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, 310058, China
2 Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310018, China
* Corresponding Author: HONG DENG. Email: email
(This article belongs to the Special Issue: Extracellular Matrix in Development and Disease)

BIOCELL https://doi.org/10.32604/biocell.2024.053983

Received 02 March 2024; Accepted 21 June 2024; Published online 15 July 2024

Abstract

In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of CAFs and their roles in the CRC tumor microenvironment, including the interaction between exosomes and CAFs in CRC. Additionally, we discuss potential therapeutic strategies targeting CAFs.

Keywords

Cancer-associated fibroblast; Colorectal cancer; Tumor microenvironment; Cancer therapy

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