Open Access

REVIEW

Modulatory role of plant-derived metabolites on host-microbiota interactions: personalized therapeutics outlook

POOJA YADAV, NAR SINGH CHAUHAN^*

Department of Biochemistry, Maharshi Dayanand University Rohtak, Rohtak, Haryana, India

* Corresponding Author: NAR SINGH CHAUHAN. Email:

(This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)

BIOCELL 2024, 48(8), 1127-1143. https://doi.org/10.32604/biocell.2024.051318

Received 02 March 2024; Accepted 10 May 2024; Issue published 02 August 2024

Abstract

A diverse array of microbes in and on the human body constitute the microbiota. These micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and illnesses. Any biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human diseases. Plant metabolites are continually being used to treat various illnesses. These metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human diseases. Despite the paramount therapeutic significance of the factors affecting host-microbiota interactions, a comprehensive overview of the modulatory role of plant-derived metabolites in host-microbiota interactions is lacking. The current review puts an effort into comprehending the role of medicinal plants in gut microbiota modulation to mitigate various human illnesses. It would develop a holistic understanding of host-microbiota interactions and the role of effectors in health and diseases.

---

Graphic Abstract

---

Keywords

---