Submit

Login Login

Register Register

Home / Journals / BIOCELL / Online First / doi:10.32604/biocell.2024.050365
Journal Menu
Special Issues
Table of Content

All issues

Online First

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

SAIB Annual Meetings

Open Access

REVIEW

Microphysiological systems for modeling gut-organ interaction

JONG HWAN SUNG*
Department of Chemical Engineering, Hongik University, Seoul, Korea
* Corresponding Author: JONG HWAN SUNG. Email: email
(This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)

BIOCELL https://doi.org/10.32604/biocell.2024.050365

Received 04 February 2024; Accepted 10 May 2024; Published online 07 June 2024

Abstract

The gut is a digestive organ that absorbs nutrients but also plays a vital role in immune response and defense against external compounds. The complex interaction between the gut microbiota and other organs including the immune system of the host has been known in various contexts, yielding the notion of ‘axes’ between the gut and other organs. While the presence of various gut-organ axes has been reported, the lack of adequate in vitro model systems for studying this interaction has restricted a deeper insight into these phenomena. Recently developed microphysiological systems (MPS), also known as organ-on-a-chip, allow researchers to study complex interactions between diverse organs, and here we provide a review of how recently developed gut-on-a-chip systems are used for building models of various diseases that were difficult to study.

Keywords

Microfluidics; Gut-liver axis; Gut-brain axis; Microphysiological systems

  • 291

    View

  • 72

    Download

  • 0

    Like

Related articles
Copyright© 2024 Tech Science Press
© 1997-2024 TSP (Henderson, USA) unless otherwise stated

Share Link