DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review

QIAO ZHOU^1,2,3, JIAN LIU^2,4, LING XIN⁴, YANYAN FANG^2,4, LEI WAN^2,4, DAN HUANG^2,4, JINCHEN GUO¹, JIANTING WEN^2,4
1 Anhui University of Chinese Medicine, Hefei, 230012, China
2 Institute of Rheumatism Prevention and Treatment of Traditional Chinese Medicine, Anhui Academy of Chinese Medicine Sciences, Hefei, 230031, China
3 Department of Rheumatism Immunity, The Second Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, 230061, China
4 Department of Rheumatism Immunity, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, 230031, China
* Address correspondence to: Qiao Zhou, zhouqiao@ahtcm.edu.cn; Jian Liu, liujianahzy@126.com
(This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)

BIOCELL https://doi.org/10.32604/biocell.2023.026698

Received 20 September 2022; Accepted 28 November 2022; Published online 12 January 2023

Download PDF

Abstract

The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age, environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease progression and medication response, as shown in this research. This review aims to update knowledge in the field of DNA methylation associated with OA to better identify the essential features of OA subtypes and pathological conditions, hence accelerating individualized treatment and precision medicine.

Keywords

Epigenetics, DNA methylation, Osteoarthritis, Pathogenesis, Precision medicine

Downloads
- Full-Text PDF
Citation Tools
- BibTex
- EndNote
- RIS

508

View
123

Download
1

Like

DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review
QIAO ZHOU, JIAN LIU, LING XIN,...

All issues

Online First

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

SAIB Annual Meetings

DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review

Abstract

Keywords

508

123

1

Further Information

Guidelines

Follow Us

Contact Us

WhatsApp:

Share Link

WeChat scan