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Exocytosis, endocytosis and recycling of secretory vesicles in neuroendocrine cells, and its regulation by cortical actin

by ANA M. CÁRDENAS^1,*, LUCIANA I. GALLO², FERNANDO D. MARENGO^2,*

1 Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, 2360102, Chile
2 Instituto de Fisiología, Biología Molecular y Neurociencias, CONICET. Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 1428, Argentina

* Corresponding Authors: Fernando D. Marengo, ; Ana M. Cárdenas,

BIOCELL 2022, 46(8), 1867-1873. https://doi.org/10.32604/biocell.2022.019086

Received 03 September 2021; Accepted 08 December 2021; Issue published 22 April 2022

Abstract

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to stimuli. This dynamic network of cortical filaments, together with motor myosin partners, adjusts the plasmalemma tension, organizes membrane protein microdomains, remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis, endocytosis and recycling of secretory vesicles. In this review, we discuss how these mechanisms work in secretory cells.

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