Open Access
REVIEW
ZEYIN LAI1, HANGYUAN ZHAO1, HONG DENG1,2,*
BIOCELL, DOI:10.32604/biocell.2024.053983
（This article belongs to the Special Issue: Extracellular Matrix in Development and Disease)
Abstract In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of More >
Open Access
REVIEW
CHUN-HUA WANG1,2, LU-KAI WANG3, RONG-YAUN SHYU4, FU-MING TSAI5,*
BIOCELL, DOI:10.32604/biocell.2024.053746
Abstract Tazarotene-induced gene 1 (TIG1) is induced by a derivative of vitamin A and is known to regulate many
important biological processes and control the development of cancer. TIG1 is widely expressed in various tissues; yet
in many cancer tissues, it is not expressed because of the methylation of its promoter. Additionally, the expression of
TIG1 in cancer cells inhibits their growth and invasion, suggesting that TIG1 acts as a tumor suppressor gene.
However, in some cancers, poor prognosis is associated with TIG1 expression, indicating its protumor growth
characteristics, especially in promoting the invasion of inflammatory breast cancer More >
Open Access
ARTICLE
HAOTONG SUN1,2,#, HEYING WANG1,2,#, YANJIE HAO1,2, XIN LI1,2, JUN LING1,2, HUAN WANG1,2, FEIMIAO WANG1,2, FANG XU1,2,*
BIOCELL, DOI:10.32604/biocell.2024.052451
（This article belongs to the Special Issue: New Perspectives on Inflammatory Cancer Transformation)
Abstract Background: Colorectal cancer is a major global health concern, exacerbated by tumor necrosis factor-alpha(TNF-α) and its role in inflammation, with the effects of Mitotic Arrest Deficient 2 Like 2 (MAD2L2) in this context still unclear. Methods: The colorectal carcinoma cell lines HCT116 and SW620 were exposed to TNF-α for a period of 24 h to instigate an inflammatory response. Subsequent assessments were conducted to measure the expression of inflammatory cytokines, the activity within the p38 mitogen-activated protein kinase (p38 MAPK) and Phosphoinositide 3-Kinase/AKT Serine/Threonine Kinase pathway (PI3K/AKT) signaling cascades. Transcriptome sequencing and subsequent integrative analysis… More >
Open Access
ARTICLE
WENBIN LUO1, YULING ZOU2, HONGXI WU3, ZHONGYI YANG1, ZHIPENG YOU2,*
BIOCELL, DOI:10.32604/biocell.2024.051045
Abstract Background: Diabetes retinopathy (DR) is a complication of diabetes that affects patients’ vision. Previous studies have found blueberry anthocyanins extract (BAE) can inhibit the progression of DR, but its mechanism is not completely clear. Methods: To study the role of BAE in diabetes retinopathy, we treated human retinal endothelial cells (HRCECs) with 30 mM high glucose to simulate the microenvironment of diabetes retinopathy and used BAE to intervene the in vitro high glucose-induced retinopathy model. HRCEC cell viability and apoptosis rates were examined by Cell Counting Kit 8 (CCK-8) assay and flow cytometry assay. The binding… More >
Open Access
REVIEW
ANJANI DEVI CHINTAGUNTA1, SAMUDRALA PRASHANT JEEVAN KUMAR2, NUNE SATYA SAMPATH KUMAR1,*
BIOCELL, DOI:10.32604/biocell.2024.050540
Abstract Depleting global petroleum reserves and skyrocketing prices coupled with succinct supply have been a grave concern, which needs alternative sources to conventional fuels. Oleaginous microalgae have been explored for enhanced lipid production, leading towards biodiesel production. These microalgae have short life cycles, require less labor, and space, and are easy to scale up. Triacylglycerol, the primary source of lipids needed to produce biodiesel, is accumulated by most microalgae. The article focuses on different types of oleaginous microalgae, which can be used as a feedstock to produce biodiesel. Lipid biosynthesis in microalgae occurs through fatty acid More >
Open Access
ARTICLE
XIAOXIAO HE1, XUEQING ZHOU2, JINPENG ZHANG2, MINGFEI ZHANG2, DANHONG ZENG2, HENG ZHANG1, SHUCAI YANG2,*
BIOCELL, DOI:10.32604/biocell.2024.052625
Abstract Objectives: This investigation aimed to elucidate the inhibitory impact of apatinib on the multidrug resistance of liver cancer both in vivo and in vitro. Methods: To establish a Hep3B/5-Fu resistant cell line, 5-Fu concentrations were gradually increased in the culture media. Hep3B/5-Fu cells drug resistance and its alleviation by apatinib were confirmed via flow cytometry and Cell Counting Kit 8 (CCK8) test. Further, Nuclear factor kappa B (NF-κB) siRNA was transfected into Hep3B/5-Fu cells to assess alterations in the expression of multidrug resistance (MDR)-related genes and proteins. Nude mice were injected with Hep3B/5-Fu cells to establish subcutaneous… More >
Open Access
ARTICLE
JI SHI1,2, YE ZHANG2, YI CHEN2, TANGJUN GUO3,*, HAOZHE PIAO2,*
BIOCELL, DOI:10.32604/biocell.2024.051049
Abstract Background: Glioblastoma multiforme (GBM) is the most general malignancy of the primary central nervous system that is characterized by high aggressiveness and lethality. Transmembrane protein 159 (TMEM159) is an endoplasmic reticulum protein that can form oligomers with seipin. The TMEM159-seipin complex decides the site of lipid droplet (LD) formation, and the formation of LDs is a marker of GBM. However, the role of TMEM159 in the progression of GBM has not been investigated to date. Methods: In this study, we examined the genes that may be associated with patient prognosis in GBM by bioinformatics analyses,… More >
Open Access
ARTICLE
XUEJIA ZHAI1,2,3,4,#, JIE LIU2,3,4,#, JINWEI XIAO2,3,4, TAO ZHANG2,3,4, JUN WANG2,3,4,5, JIANJUN LI1,*, SHICANG YU2,3,4,5,*
BIOCELL, DOI:10.32604/biocell.2024.050803
Abstract Background: Protein lactylation is a new way for the “metabolic waste” lactic acid to perform novel functions. Nevertheless, our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains imited. The construction of a scoring system for lactylation to predict the prognosis of pan-cancer patients and to evaluate the tumor immune microenvironment (TIME) would improve our understanding of the clinical significance of lactylation. Methods: Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma (PAAD) patients. Subsequently, a scoring system was developed using the least absolute shrinkage… More >
Open Access
ARTICLE
KEWEI CHENG1, LEI SHI1, CAIWEN SHI1, SHUANSHUAN XIE2, CHANGHUI WANG2,*
BIOCELL, DOI:10.32604/biocell.2024.049626
Abstract Objective: To explore the role of polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) in lung adenocarcinoma (LUAD). Methods: Bioinformatics tools were utilized to examine the clinical profile of PKHD1L1 and chromobox protein homolog 7 (CBX7) in LUAD. The Cell Counting Kit-8, colony formation, terminal deoxynucleotidyl transferase dUTP nick end labeling, Transwell, and wound-healing assays were carried out to assess the proliferative, apoptotic, invasive, and migrative capacities of the cells. Furthermore, the interrelation between PKHD1L1 and CBX7 was validated using a co-immunoprecipitation assay. A LUAD mice model was constructed by subcutaneous injection of A549 cells.… More >
Open Access
ARTICLE
LINPEI WANG1,2, JIAWEI WANG2, CHUNFENG SHI2, WEI WANG2,*, JIAN WU1,*
BIOCELL, DOI:10.32604/biocell.2024.051756
Abstract Background: Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) is a depalmitoylation enzyme that removes the S-palmitoylation of targeted proteins. The hepatocellular carcinoma (HCC) cells SNU449 and Hep3B use ABHD17C as an oncogene; however, the exact mechanism of this action is yet unknown. Methods: The expression of ABHD17C in liver cancer tissues was analyzed by bioinformatics, and the expression of ABHD17C in clinical liver cancer tissues and adjacent normal tissues was detected. Then, the proliferative viability of HCC cells after overexpression or knockdown of ABHD17C was examined, and pyroptosis and apoptosis proteins were detected. Results: ABHD17C was overexpressed in More >
Open Access
REVIEW
TINGTING LIU#, DINGYOU GUO#, JIANSHE WEI*
BIOCELL, DOI:10.32604/biocell.2024.051518
（This article belongs to the Special Issue: Exploring the Cellular Mechanisms of Neurodegenerative Diseases)
Abstract In China, Parkinson’s disease (PD) is the second most prevalent central nervous system (CNS) degenerative illness affecting middle-aged and older persons. Movement disorders including resting tremor, bradykinesia, myotonia, postural instability, and gait instability are the predominant clinical symptoms. The two main types of PD are sporadic and familial, with sporadic PD being the more prevalent of the two. The environment, genetics, mitochondrial dysfunction, oxidative stress, inflammation, protein aggregation and misfolding, loss of trophic factors, cell death, and gut microbiota may all have a role in the etiology of PD. PD is inversely connected with other More >
Open Access
ARTICLE
SHAN JIANG1,2, XIUFENG LIN2, YANFEI CHEN3, XINNING LI3, JIALI KANG1,4,*
BIOCELL, DOI:10.32604/biocell.2024.051478
（This article belongs to the Special Issue: Subcellular Organelles and Cellular Molecules: Localization, Detection, Prediction, and Diseases)
Abstract Background: Despite improvements in objective response rates to cisplatin-based combination chemotherapy, the majority of advanced ovarian cancer remains suboptimal, resulting in poor survival. it has been found that non-coding RNAs (ncRNAs) not only participate in the transmission of signals between various cells but also participate in tumor immunity and anti-tumor immune responses, thereby regulating tumor occurrence and development. However, the function and detailed mechanism of ultraconserved RNA (ucRNA) in ovarian cancer chemoresistance is still unclear. Methods: Western blotting assay, Quantitative real-time PCR analysis (qPCR), and Kaplan-Meier Plotter analysis were performed to analyze the expression and prognosis… More >
Open Access
REVIEW
POOJA YADAV, NAR SINGH CHAUHAN*
BIOCELL, DOI:10.32604/biocell.2024.051318
（This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)
Abstract A diverse array of microbes in and on the human body constitute the microbiota. These micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and illnesses. Any biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human diseases. Plant metabolites are continually being used to treat various illnesses. These metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human diseases. Despite the paramount therapeutic significance of the factors affecting host-microbiota interactions, a comprehensive overview of More >
Graphic Abstract
Open Access
REVIEW
JONG HWAN SUNG*
BIOCELL, DOI:10.32604/biocell.2024.050365
（This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)
Abstract The gut is a digestive organ that absorbs nutrients but also plays a vital role in immune response and defense against external compounds. The complex interaction between the gut microbiota and other organs including the immune system of the host has been known in various contexts, yielding the notion of ‘axes’ between the gut and other organs. While the presence of various gut-organ axes has been reported, the lack of adequate in vitro model systems for studying this interaction has restricted a deeper insight into these phenomena. Recently developed microphysiological systems (MPS), also known as organ-on-a-chip, More >
Open Access
ARTICLE
MARYNA TKACHENKO1, ANATOLII ONISHCHENKO2, LILIYA TRYFONYUK3, DMYTRO BUTOV4, KATERYNA KOT5, VIKTORIIA NOVIKOVA6, LIWEI FAN5,7, VOLODYMYR PROKOPIUK2,8, YURII KOT5,*, ANTON TKACHENKO2,*
BIOCELL, DOI:10.32604/biocell.2024.050206
（This article belongs to the Special Issue: Cell Death in Health and Disease: Diversity, Complexity, and Dynamics)
Abstract Introduction: Human chemerin is an adipokine that regulates chemotaxis, inflammation, and glucose metabolism. In addition, accumulating evidence suggests that chemerin promotes apoptosis, autophagy, and pyroptosis. However, there are no data on its impact on eryptosis. The current study aimed to analyze the effects of human active Glu-Ser chemerin on eryptosis in vitro. Materials and Methods: Human chemerin 0-2-10-50 µg/mL was incubated for 24 h with human erythrocytes (hematocrit 0.4%) obtained from eight healthy individuals. Flow cytometry-based determination of phospholipid scrambling, reactive oxygen species (ROS) production, and intracellular Ca levels was performed. To supplement data on ROS and Ca… More >
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