Open Access
ARTICLE
Kuo-Yang Huang1, Sheng-Chien Lin2,3, Chun-Hung Su4,5,6, Sheng-Wen Wu4,7, Ching-Chi Tseng8,9, Wei-Chin Hung10, Shih-Pin Chen4,5, Yu-Hsiang Kuan2,3,*
BIOCELL, DOI:10.32604/biocell.2025.061073
(This article belongs to the Special Issue: Cellular and Molecular Mechanisms Underlying Inflammation and Immune Regulation: From Genotoxicity to Apoptosis)
Abstract Background: Acute respiratory distress syndrome (ARDS) is the major therapeutic dilemma associated with significant inflammation and severe pulmonary dysfunction. Liriodendrin is a bioactive compound extract from traditional Chinese medicine, historically utilized for modulating inflammatory responses and alleviating symptoms in multiple disease models. Methods: At present, BALB/c mice to explore the effects of liriodendrin on lipopolysaccharide (LPS)-induced ARDS. Before LPS was administered, the mice were treated with either liriodendrin or dexamethasone. Leukocyte infiltration, lung edema, and alveolar-capillary barrier integrity were evaluated in the bronchoalveolar lavage fluid (BALF) and pulmonary parenchyma. The expression of adhesion molecules and… More >
Open Access
REVIEW
Giuseppe Carota1, Lucia Di Pietro2,3, Vincenzo Cardaci4, Anna Privitera1,2, Francesco Bellia1, Valentina Di Pietro5, Giuseppe Lazzarino1, Barbara Tavazzi6, Angela Maria Amorini1, Giacomo Lazzarino6, Giuseppe Caruso6,7,*
BIOCELL, DOI:10.32604/biocell.2025.062176
(This article belongs to the Special Issue: Macrophages and Microglia Dysfunction in Systemic and Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets)
Abstract Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely distributed in excitable tissues, such as the heart and brain. Over the years, several beneficial effects of carnosine have been discussed well in scientific literature. In particular, this dipeptide is well-known for its antioxidant, anti-inflammatory, and anti-aggregation activities. It is of great interest in the context of numerous systemic and neurodegenerative diseases, besides performing important “side activities” such as metal chelation and pH-buffering. Despite a plethora of preclinical and clinical data supporting carnosine’s therapeutic potential, researchers are still searching for new pharmacological targets that better highlight More >
Open Access
REVIEW
Nathan Isaac Dibal1,*, Martha Orendu Oche Attah1,2
BIOCELL, DOI:10.32604/biocell.2025.060565
(This article belongs to the Special Issue: Mitochondrial Dynamics and Oxidative Stress in Disease: Cellular Mechanisms and Therapeutic Targets)
Abstract Oxidative stress is characterized by elevated intracellular reactive oxygen species (ROS) levels. At physiological levels, ROS work as signaling molecules, helping cells go through the cell cycle normally and keeping their balance. They also balance several physiological processes. However, a shift in the delicate balance between antioxidants and ROS results in aberrant cell death and deleterious effects. Elevated ROS is implicated in many diseases and disorders like diabetes, autoimmune diseases, infertility, and cardiovascular disorders. The imbalance disrupts normal cellular functions, including cell division. ROS are important regulators of the cell cycle, exerting both favorable and More >
Open Access
COMMENTARY
Qian Yang, Alina Leonie Ruff, Lydia Meder*
BIOCELL, DOI:10.32604/biocell.2025.060227
(This article belongs to the Special Issue: Genetic Biomarkers of Cancer: Insights into Molecular and Cellular Mechanisms)
Abstract This article has no abstract. More >
Open Access
REVIEW
Olga Koval1,2,*, Maria Zhilnikova1, Maria Balantaeva1,2, Mikhail Biryukov1,2, Vasiliy Atamanov1,3
BIOCELL, DOI:10.32604/biocell.2025.059987
(This article belongs to the Special Issue: Cell Death and Inflammation in Signaling and Diseases)
Abstract Melanomas are aggressive cancers, with a high rate of metastatic disease. Cutaneous (CM) and uveal (UM) melanomas are intrinsically different diseases, and most cell death inducers effective for CM do not function for UM. This is primarily due to the fact the eye is an immunologically privileged organ, and it fails to achieve the efficacy of immune checkpoint inhibitors (ICIs) comparable to that for CM. However, approaches utilizing specific melanoma-associated antigens are being developed for metastatic forms of CM and UM. The most promising to date are gp100 and tyrosinase related protein 1 (TYRP1), primarily… More >
Open Access
REVIEW
Sahel Abyar1,2, Shahrzad Shoraka2, Seyed Masoud Hosseini2, Mohammad Reza Zali3, Seyed Reza Mohebbi3,*
BIOCELL, DOI:10.32604/biocell.2025.059787
(This article belongs to the Special Issue: Exploring Mitochondria: Unraveling Structure, Function, and Implications in Health and Disease)
Abstract Oncogenic viruses include both DNA and RNA viruses which contribute to cancer development by disrupting cellular regulation and interfering in the immune responses. These viruses do not directly cause cancer but instead integrate their genetic material into the host genome thus, affecting cell cycle and tumor suppression. This deregulation also leads to impaired immune function and promotes tumor progression by disrupting the removal of infected cells. Generally, innate immunity consists of two important members, including mitochondria and cell deaths, which impact each other as well. Due to the close correlation between viruses, cell death pathways… More >
Open Access
ARTICLE
Juan Cheng1,#, Zhiwei Zhao2,#, Ling Wang1, Jirui Wen1, Yali Miao3,*, Jiang Wu1,*
BIOCELL, DOI:10.32604/biocell.2025.059573
Abstract Objectives: Recently, pre-/post-operative Local Estrogen Therapy (LET) has shown effectiveness in alleviating Pelvic Organ Prolapse (POP) symptoms in clinical therapy. However, there is a lack of scientific evidence to support these claims. Therefore, we aimed to explore the anti-senescence effects and mechanisms of 17β-estradiol (E2) on POP-derived fibroblasts. Methods: The primary fibroblast cells were isolated and cultured from the surgical samples of postmenopausal women clinically diagnosed with pelvic organ prolapse (POP) at stages III-IV (quantified using the POP-Q system) and without any other treatment within 6 months. (n = 12, age 50–75). Colorimetric Cell Counting… More >
Open Access
REVIEW
Francesco Triggiano#, Giusy Diella#, Mara Lorusso, Paolo Veneziani*, Marilena D’Ambrosio, Daniela Nesta, Luigi Santacroce*
BIOCELL, DOI:10.32604/biocell.2025.059322
Abstract The composition of the vaginal microbiota (VMB) influences the health of the female reproductive tract. Several studies have shown how the absence of lactobacilli causes an imbalance in the vaginal microbial community, favoring the development of infections. The present study aims to evaluate the relationship between the VMB and human papillomavirus (HPV) infection to clarify the role of the vaginal microbiota in the persistence and clearance of HPV. Many researchers have provided the scientific community with information on the composition of the microbiota and how it may also influence HPV infection and the development of… More >
Open Access
ARTICLE
Chang-Eui Hong1, Su-Yun Lyu2,*
BIOCELL, DOI:10.32604/biocell.2025.060411
(This article belongs to the Special Issue: Molecular Mechanisms of Natural Compounds in Cell Signaling and Cancer Therapy)
Abstract Objectives: Despite progress in therapeutic interventions, squamous cell carcinoma of the oral cavity (OSCC) continues to pose a substantial burden on public health, with persistently poor patient outcomes. This investigation examines the growth-inhibitory and mechanistic effects of a plant-derived protein, Viscum album var. coloratum agglutinin (VCA), extracted from Korean mistletoe, against YD38 OSCC cells. Methods: The experimental protocols involved treating YD38 cells derived from human OSCC with escalating doses of VCA. Cell survival rates were quantified through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric analysis. Changes in apoptotic indices and cell cycle distribution were evaluated using flow cytometric techniques. Protein… More >
Open Access
ARTICLE
Lingling Zhang1,2, Hualing Wang3, Yawen Liu2, Ling Li2,*, Jianping Xiong1,4,*
BIOCELL, DOI:10.32604/biocell.2025.061585
(This article belongs to the Special Issue: Genetic Biomarkers of Cancer: Insights into Molecular and Cellular Mechanisms)
Abstract Objective: Anillin (ANLN) is considered an oncogene in various cancers, but its effect on cervical cancer remains poorly understood. Hence, this study aimed to describe the action of ANLN on cervical cancer development and investigate the potential mechanism. Methods: Analysis of ANLN expression and its association with survival in carcinoma and endocervical adenocarcinoma (CESC) patients based on GEO and UALCAN databases. The tumor and adjacent normal tissues of 100 cervical cancer cases were harvested to detect the ANLN expression and explore its relationship with patient survival. Cell proliferation, apoptosis, migration, and invasion were measured by… More >
Open Access
REVIEW
Juan Yang1,2,#, Jiahui Zhang3,#, Le Zhang1,2,*, Zhenshan Yang4,*
BIOCELL, DOI:10.32604/biocell.2025.059908
(This article belongs to the Special Issue: Mitochondrial Dynamics and Oxidative Stress in Disease: Cellular Mechanisms and Therapeutic Targets)
Abstract With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to More >
Open Access
REVIEW
Emmanuel Mago1, Jiayi Xu1, Dan Weng1,*, Yan Pan2,*
BIOCELL, DOI:10.32604/biocell.2025.059432
(This article belongs to the Special Issue: Cell Death and Inflammation in Signaling and Diseases)
Abstract Z-DNA binding protein 1 (ZBP1) has emerged as a critical player in cancer biology, functioning as a cytosolic nucleic acid sensor that triggers PANoptosis, a form of programmed cell death that integrates pyroptosis, apoptosis, and necroptosis. Although ZBP1 was initially recognized for its role in antiviral defense, recent research has highlighted its importance in the tumor microenvironment (TME), where it is essential for suppressing tumor growth and proliferation. This review explores the multifaceted role of ZBP1 in various cancer types, emphasizing its ability to detect Z-nucleic acids and double-stranded RNAs, leading to the initiation of… More >
Open Access
REVIEW
Sha Chen1,#, Minkai Cao1,#, Kerong Liu2,*, Ying Gu1,*
BIOCELL, DOI:10.32604/biocell.2025.058745
Abstract The increasing prevalence of gestational diabetes mellitus (GDM) is associated with an array of pregnancy complications and enduring health challenges in both mothers and their offspring. Studies have indicated that exposure to the intrauterine environment can prompt adaptations in the offspring, thereby programming transgenerational inheritance. Physical activity during pregnancy, as a non-pharmacological intervention, mitigates metabolic risks through epigenetic modifications, mediating placental adaptations, the action of exercise factors, and gut microbiota. Here, we provide a review summarizing how regular exercise can reduce the risk of GDM and positively influence pregnancy outcomes. It also discusses the exercise-induced More >
Open Access
REVIEW
Long Qi1, Chaoran Wu1, Hao Sun1,2,*, Hong Liao1,*
BIOCELL, DOI:10.32604/biocell.2025.059159
(This article belongs to the Special Issue: Cell Death and Inflammation in Signaling and Diseases)
Abstract Glutamate is an essential excitatory neurotransmitter in the brain, playing a vital role in regulating synaptic activity and maintaining the homeostasis of the cerebral environment but also serves as a central hub for neuronal injury and inflammatory responses. In various pathological conditions, such as ischemic stroke, glutamate is released and accumulates excessively in the brain, leading to heightened stimulation of neurons and excitotoxicity. This phenomenon positions glutamate as a primary inducing factor for neuronal damage following cerebral ischemia. Glutamate exerts its effects primarily through two types of receptors: ionotropic and metabotropic glutamate receptors, both of… More >