BIOCELL is an international, peer-reviewed, open access journal on molecular and cellular biosciences. The journal welcomes high quality original research articles, review papers, communications, perspectives, commentaries, etc. Topics of interests include but are not limited to: Cellular Biochemistry, Structural & Molecular Biology, Cellular/Molecular Biology, Immunology, Pathology & Neurobiology, Cell Signaling, Regenerative Biology & Stem Cells, Cancer Biology, RNA Biology, Genomics, Transcriptomics, Proteomics & Metabolomics, Plant Molecular & Cellular Biology.
Science Citation Index Expanded (SCIE): 2023 Impact Factor 0.8; Journal Citation Report/Science Edition (JCR); Scopus; Scopus Citescore (Impact per Publication 2023): 1.5; SNIP (Source Normalized Impact per Paper 2023): 0.226; Sociedad Argentina de Investigaciones en Bioquímica y Biología Molecular (SAIB); Portico, etc.
Open Access
COMMENTARY
BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024
Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >
Open Access
REVIEW
BIOCELL, Vol.48, No.11, pp. 1521-1529, 2024, DOI:10.32604/biocell.2024.055410 - 07 November 2024
Abstract Cellular biomechanical features contributed to the occurrence and development of various physiological and pathological phenomena. Micropillar arrays have emerged as an important tool for both the assessment and manipulation of cellular biomechanical characteristics. This comprehensive review provides an in-depth understanding of the fabrication methodologies of micropillar arrays and their applications in deciphering and fine-tuning cellular biomechanical properties and the innovative experimental platforms including organ-on-a-chip and organoids-on-a-chip. This review provides novel insights into the potential of micropillar technology, poised to update the landscape of stem cell research and tissue engineering. More >
Open Access
REVIEW
BIOCELL, Vol.48, No.11, pp. 1531-1542, 2024, DOI:10.32604/biocell.2024.054278 - 07 November 2024
Abstract Stem cells have shown great application potential in wound repair, tissue regeneration, and disease treatment. Therefore, a full understanding of stem cells and their related regulatory mechanisms in disease treatment is conducive to improving the therapeutic effect of stem cells. However, thus far, there are still many unsolved mysteries in the field of stem cells due to technical limitations, which hinder the in-depth exploration of stem cells and their wide clinical application. Single-cell sequencing (SCS) has provided very powerful and unbiased insights into cell gene expression profiles at the single-cell level, bringing exciting results to More >
Open Access
REVIEW
BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505 - 07 November 2024
(This article belongs to the Special Issue: Non-coding RNAs (ncRNAs) in Human Diseases)
Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >
Open Access
REVIEW
BIOCELL, Vol.48, No.11, pp. 1569-1578, 2024, DOI:10.32604/biocell.2024.053983 - 07 November 2024
(This article belongs to the Special Issue: Extracellular Matrix in Development and Disease)
Abstract In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of More >
Open Access
REVIEW
BIOCELL, Vol.48, No.11, pp. 1579-1602, 2024, DOI:10.32604/biocell.2024.054879 - 07 November 2024
(This article belongs to the Special Issue: Genetic Biomarkers of Cancer: Insights into Molecular and Cellular Mechanisms)
Abstract Nanoparticles represent a heterogeneous collection of materials, whether natural or synthetic, with dimensions aligning in the nanoscale. Because of their intense manifestation with the immune system, they can be harvested for numerous bio-medical and biotechnological advancements mainly in cancer treatment. This review article aims to scrutinize various types of nanoparticles that interact differently with immune cells like macrophages, dendritic cells, T lymphocytes, and natural killer (NK) cells. It also underscores the importance of knowing how nanoparticles influence immune cell functions, such as the production of cytokines and the presentation of antigens which are crucial for… More >
Open Access
ARTICLE
BIOCELL, Vol.48, No.11, pp. 1603-1612, 2024, DOI:10.32604/biocell.2024.054364 - 07 November 2024
(This article belongs to the Special Issue: Navigating the Interplay of Cancer, Autophagy, ER Stress, Cell Cycle and Apoptosis: Mechanisms, Therapies, and Future Directions)
Abstract Objectives: The antitumor effects of pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) were observed in several cancers. The objective of this investigation was to examine the antineoplastic efficacy of MPPa-PDT acting on lung carcinoma A549 cells and further elaborate mechanisms. Methods: The viability of A549 cells was examined with cell counting kit-8 after MPPa-PDT disposal. Hoechst 33342 staining, monodansylcadaverine (MDC) staining, and transmission electron microscopy were employed to observe apoptotic bodies and autophagic vesicles. Flow cytometry with Annexin V/propidium iodide (PI) labeling objectively assessed cell death. The expression of associated proteins, including Caspase-3, Beclin-1, LC-3II, and More >
Graphic Abstract
Open Access
ARTICLE
BIOCELL, Vol.48, No.11, pp. 1613-1623, 2024, DOI:10.32604/biocell.2024.053652 - 07 November 2024
Abstract Objectives: This study explores the protective effects of glycyrrhizic acid (GA) on sepsis-induced cellular damage and inflammation in acute lung injury (ALI), specifically through the modulation of the sirtuin 1 (SIRT1) and high mobility group box 1 (HMGB1) pathway. Methods: The study employed two experimental models: lipopolysaccharide (LPS)-induced BEAS-2B human lung epithelial cells and cecal ligation and puncture (CLP) rats, to simulate sepsis conditions. The cell model involved treatments with LPS, GA, control siRNA (si-NC), and SIRT1-specific siRNA (si-SIRT1). Evaluations included cell viability, apoptosis, and cytokine production. In the rat model, treatments included GA and… More >
Open Access
ARTICLE
BIOCELL, Vol.48, No.11, pp. 1625-1638, 2024, DOI:10.32604/biocell.2024.055029 - 07 November 2024
Abstract Objective: The study aimed to explore the protective mechanism of Ganoderic acid A (GAA) in renal fibrosis and to verify that GAA can ameliorate renal fibrosis by regulating the Niemann-pick C1-like 1 (NPC1L1) gene. Methods: Transforming growth factor beta1 (TGF-β1) was used to treat Human Kidney-2 (HK-2) cells to establish a renal fibrosis model. The differentially expressed genes in the control (CTRL) group, TGF-β1 group, and TGF-β1 + GAA group were screened via transcriptome sequencing technology and verified by qPCR and Western blot experiments. The NPC1L1 gene overexpression plasmid was constructed. The expression levels of N-cad, E-cad,… More >