Open Access

ARTICLE

Retrospective Analysis of Postprandial Glucose-Response Data Collected in a Free-Living Environment

by Colleen Crangle^1,2,*, Bude Piccin², Lara Hyde³, Elin Östman⁴

1 Converspeech Limited Liability Company, Palo Alto, 94301, Canada
2 Tastermonial, Palo Alto, 95014, Canada
3 Nourishable, Litchfield, 03052, America
4 Aventure AB Company, Lund, 26151, Sweden

* Corresponding Author: Colleen Crangle. Email:

Journal of Intelligent Medicine and Healthcare 2022, 1(2), 91-102. https://doi.org/10.32604/jimh.2022.038379

Received 10 November 2022; Accepted 12 December 2022; Issue published 05 January 2023

Abstract

Postprandial glucose responses provide vital information on an individual’s risk of major diet-related chronic diseases. This study features digital health technology, namely Continuous Glucose Monitoring (CGM) sensors, along with mobile devices (iPhones running an app) used to collect data from individuals and their environment, specifically nutritional information on what they eat and drink. The paper presents a retrospective analysis of data collected during an investigation into the use of a functional drink taken as a supplement with a standardized meal to reduce postprandial responses to that meal. Given that there are consequential differences between individuals in their postprandial glucose responses, these real-world data are analyzed at the level of the individual. The aim of the study was to assess the feasibility of collecting real-world data on supplements and postprandial glucose responses outside of a controlled laboratory environment, synthesizing the data from the different sources, and producing individualized results. Of the 40 individuals invited to conduct 6 tests, 3 with and 3 without the supplement, 19 provided from 1 to 6 valid tests, producing 0 to 6 comparisons each. Four individuals contributed at least 5 comparisons each, the minimum number required for the exact 1-sided Wilcoxon signed-rank test. The conclusion is that a real-world study of supplements and postprandial glucose responses is feasible, with an increase in the number of tests requested of each individual, a simplification of the testing protocol, and steps taken to reduce the number of invalid tests.

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Keywords

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