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The Electrophysiology of Semantic Processing in Individuals with Autism Spectrum Disorder: A Meta-Analysis

Danfeng Yuan1, Xiangyun Yang1, Lijuan Yang1, Zhanjiang Li1,2,*

1 The National Clinical Research Center for Mental Disorder & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
2 Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China

* Corresponding Author: Zhanjiang Li. Email: email

(This article belongs to the Special Issue: Mental Health and Social Development)

International Journal of Mental Health Promotion 2023, 25(10), 1067-1079. https://doi.org/10.32604/ijmhp.2023.041430

Abstract

Language difficulties vary widely among people with autism spectrum disorder (ASD). However, the semantic processing of autistic person and its underlying electrophysiological mechanism are still unclear. This meta-analysis aimed to explore the disturbance of semantic processing in patients with ASD. PubMed, Web of Science, and Embase were searched for event-related potential (ERP) studies on semantic processing in autistic people published in English before September 01, 2022. Pooled estimates were calculated by fixed-effects or random-effects models according to the heterogeneity using Comprehensive Meta-Analysis 2.0. The potential moderators were explored by meta-regression and subgroup analysis. This meta-analysis has been registered at the Prospero International Prospective Register of Systematic Reviews (no. CRD 42021265852). A total of 14 articles and 18 studies, including 254 autistic people and 262 neurodevelopmental people were included in this meta-analysis. Compared to the comparison group, autistic people showed an overall reduced N400 amplitude (Hedges’ g = 0.350, p < 0.001) in response to linguistic stimuli instead of non-linguistic stimuli. The N400 amplitude was affected by verbal intelligence and gender. The reduced overall N400 amplitude in autistic people under linguistic stimuli suggests a linguistic-specific deficit in semantic processing in individuals of autism. The decrease of N400 amplitude might be a promising indication of the pool language capacity of autism.

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APA Style
Yuan, D., Yang, X., Yang, L., Li, Z. (2023). The electrophysiology of semantic processing in individuals with autism spectrum disorder: A meta-analysis. International Journal of Mental Health Promotion, 25(10), 1067-1079. https://doi.org/10.32604/ijmhp.2023.041430
Vancouver Style
Yuan D, Yang X, Yang L, Li Z. The electrophysiology of semantic processing in individuals with autism spectrum disorder: A meta-analysis. Int J Ment Health Promot. 2023;25(10):1067-1079 https://doi.org/10.32604/ijmhp.2023.041430
IEEE Style
D. Yuan, X. Yang, L. Yang, and Z. Li, “The Electrophysiology of Semantic Processing in Individuals with Autism Spectrum Disorder: A Meta-Analysis,” Int. J. Ment. Health Promot., vol. 25, no. 10, pp. 1067-1079, 2023. https://doi.org/10.32604/ijmhp.2023.041430



cc Copyright © 2023 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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