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Sustained Drug Release from Contact Lenses

J.A.Ferreira2,3, P. Oliveira1, P.M. Silva4, A. Carreira5,3, J.N. Murta6
This work was partially supported by Projects: PTDC/MAT/74548/2006, UTAustin/MAT/0066/2008
CMUC, Department of Mathematics, University of Coimbra, Largo D. Dinis, 3001 - 454 Coimbra, Portugal
Email of the corresponding author: ferreira@mat.uc.pt
Department of Physics and Mathematics, ISEC, Rua Pedro Nunes, Quinta da Nora, 3030-199Coimbra, Portugal
Department of Chemical Engineering, Rua Sílvio Lima, Pólo II, 3030-790 Coimbra Portugal
Department of Ophthalmology, Faculty of Medicine, University of Coimbra, 3001 - 454 Coimbra, Portugal

Computer Modeling in Engineering & Sciences 2010, 60(2), 151-180. https://doi.org/10.3970/cmes.2010.060.151

Abstract

This paper focuses on the release of an ophthalmic drug (flurbiprofen) from a loaded copolymer where the drug is simultaneously dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. In vitro experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.

Keywords

Ophthalmic drug delivery, contact lenses, p-(HEMA/MAA), reaction-diffusion equation, qualitative behavior, in vitro experiments, simulation results.

Cite This Article

, J., Oliveira, P., Silva, P., Carreira, A., Murta, J. (2010). Sustained Drug Release from Contact Lenses. CMES-Computer Modeling in Engineering & Sciences, 60(2), 151–180.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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