Open Access

ARTICLE

Isogeometric Analysis of Hyperelastic Material Characteristics for Calcified Aortic Valve

by Long Chen¹, Ting Li¹, Liang Liu¹, Wenshuo Wang^2,*, Xiaoxiao Du³, Wei Wang³

1 School of Mechanical Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China
2 Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200093, China
3 School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China

* Corresponding Author: Wenshuo Wang. Email:

Computer Modeling in Engineering & Sciences 2024, 139(3), 2773-2806. https://doi.org/10.32604/cmes.2024.046641

Received 09 October 2023; Accepted 25 December 2023; Issue published 11 March 2024

Abstract

This study explores the implementation of computed tomography (CT) reconstruction and simulation techniques for patient-specific valves, aiming to dissect the mechanical attributes of calcified valves within transcatheter heart valve replacement (TAVR) procedures. In order to facilitate this exploration, it derives pertinent formulas for 3D multi-material isogeometric hyperelastic analysis based on Hounsfield unit (HU) values, thereby unlocking foundational capabilities for isogeometric analysis in calcified aortic valves. A series of uniaxial and biaxial tensile tests is executed to obtain an accurate constitutive model for calcified active valves. To mitigate discretization errors, methodologies for reconstructing volumetric parametric models, integrating both geometric and material attributes, are introduced. Applying these analytical formulas, constitutive models, and precise analytical models to isogeometric analyses of calcified valves, the research ascertains their close alignment with experimental results through the close fit in displacement-stress curves, compellingly validating the accuracy and reliability of the method. This study presents a step-by-step approach to analyzing the mechanical characteristics of patient-specific valves obtained from CT images, holding significant clinical implications and assisting in the selection of treatment strategies and surgical intervention approaches in TAVR procedures.

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Graphic Abstract

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