Vol.121, No.3, 2019, pp.787-800, doi:10.32604/cmes.2019.07159
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ARTICLE
Computational Study of Collective Cell Migration By Meshfree Method
  • Jie Bai1,#, Liqiang Lin1,#, Xiaowei Zeng 1,*
1 Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
# These two authors contributed equally to this work.
* Corresponding Author: Xiaowei Zeng. Email: xiaowei.zeng@utsa.edu.
Abstract
The collective cell migration behavior on a substrate was studied using RKPM meshfree method. The cells were modeled as nematic liquid crystal with hyperelastic cell nucleus. The cell-substrate and cell-cell interactions were modeled by coarse-grained potential forces. Through this study, the pulling and pushing phenomenon during collective cell migration process was observed and it was found that the individual cell mobility significantly influenced the collective cell migratory behavior. More self-propelled cells are in the system along the same direction, the faster the collective group migrates toward coordinated direction. The parametric study on cell-cell adhesion strength indicated that as the adhesion strength increases, the collective cell migration speed increases. It also showed that the mechanical stress in leader cell is higher than stress in follower cells.
Keywords
Cell-cell interaction, cell-substrate interaction, collective cell migration, meshfree method, numerical simulation.
Cite This Article
Bai, J., Lin, L., Zeng, X. (2019). Computational Study of Collective Cell Migration By Meshfree Method. CMES-Computer Modeling in Engineering & Sciences, 121(3), 787–800.
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