Open Access

ARTICLE

A Numerical Study of Passive Receptor-Mediated Endocytosis of Nanoparticles: The Effect of Mechanical Properties

by Xinyue Liu¹, Yunqiao Liu¹, Xiaobo Gong¹, Huaxiong Huang²

1 Key Laboratory of Hydrodynamics (Ministry of Education), Department of Engineering Mechanic, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
2 Department of Mathematics and Statistics, York University, Toronto, Ontario, M3J1P3, Canada.

*Corresponding Author: Xiaobo Gong. Email: .

(This article belongs to the Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)

Computer Modeling in Engineering & Sciences 2018, 116(2), 281-300. https://doi.org/10.31614/cmes.2018.04989

Abstract

In this work, a three-dimensional axisymmetric model with nanoparticle, receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparticles in drug delivery. The minimization of the system energy function was carried out numerically, and the deformations of nanoparticle, receptor-ligand bonds and cell membrane were predicted. Results show that passive endocytosis may fail due to the rupture of receptor-ligand bonds during the wrapping process, and the size and rigidity of nanoparticles affect the total deformation energy and the terminal wrapping stage. Our results suggest that, in addition to the energy requirement, the success of passive endocytosis also depends on the maximum strength of the receptor-ligand bonds.

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Keywords

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