Open Access

ARTICLE

Angle of Attack Between Blood Flow and Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy: An In Vivo Multi-patient CT-based FSI Study

Long Deng¹, Xueying Huang^2,3,*, Heng Zuo⁴, Yuan Zheng², Chun Yang⁵, Yunhu Song¹, Dalin Tang⁶

1 Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
2 School of Mathematical Sciences, Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computation, Xiamen University, Xiamen, Fujian, China.
3 Department of Mathematical Sciences, Worcester Polytechnic Institute, MA, USA.
4 School of Mathematical Sciences, Sichuan Normal University, Chengdu, Sichuan, China.
5 China Information Technology Designing & Consulting Institute Co., Ltd., Beijing, China.
6 School of Biological Science & Medical Engineering, Southeast University, Nanjing, China.

* Corresponding Author: Xueying Huang. Email: .

(This article belongs to the Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)

Computer Modeling in Engineering & Sciences 2018, 116(2), 115-125. https://doi.org/10.31614/cmes.2018.04076

Abstract

The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t wao vs. 56.2±56.o, p=0.306, n=5). Therefore, we propose that the angle of attack might not play an important role in the initiation of SAM.

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Keywords

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