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Dimensionless Study on Secretion Clearance of a Pressure Controlled Mechanical Ventilation System with Double Lungs

Dongkai Shen1,2,+, Qian Zhang1, Yixuan Wang1,*, Huiqing Ge3,*, Zujin Luo4,+
School of Automation Science and Electrical Engineering, Beihang University, Beijing, PR China.
The State Key Laboratory of Fluid Power Transmission and Control, Zhejiang University, Hangzhou, China .
Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China.
Department of Respiratory and Critical Care Medicine, Beijing Engineering Research Center of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao -Yang Hospital, Capital Medical University, Beijing 100043, China.
+ These two authors should be regarded as Joint First Authors.
*Corresponding author: Yixuan Wang. Email: ; Huiqing Ge. Email: .

Computer Modeling in Engineering & Sciences 2018, 114(2), 117-139.


A pressure controlled mechanical ventilator with an automatic secretion clearance function can improve secretion clearance safely and efficiently. Studies on secretion clearance by pressure controlled systems show that these are suited for clinical applications. However, these studies are based on a single lung electric model and neglect the coupling between the two lungs. The research methods applied are too complex for the analysis of a multi-parameter system. In order to understand the functioning of the human respiratory system, this paper develops a dimensionless mathematical model of double-lung mechanical ventilation system with a secretion clearance function. An experiment is designed to verify the mathematical model through comparison of dimensionless experimental data and dimensionless simulation data. Finally, the coupling between the two lungs is studied, and an orthogonal experiment designed to identify the impact of each parameter on the system.


Dimensionless system, mechanical ventilation, secretion clearance, double lungs, pressure control.

Cite This Article

Shen, D., Zhang, Q., Wang, Y., Ge, H., Luo, Z. (2018). Dimensionless Study on Secretion Clearance of a Pressure Controlled Mechanical Ventilation System with Double Lungs. CMES-Computer Modeling in Engineering & Sciences, 114(2), 117–139.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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