Open Access
ARTICLE
Piceatannol attenuates streptozotocin-induced type 1 diabetes in mice
MENGSHU ZHAO1, PINGSHI GAO1, LIANG TAO1, JINGJING WEN1, LEI WANG1, YUGUO YI1, YUXIN CHEN2, JUNSONG WANG1, XI XU1, JIANFA ZHANG1, DAN WENG1,*
1 School of Environmental and Biological Engineering, Nanjing University of Science & Technology, Nanjing, 210094, China
2 Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China
* Address correspondence to: Dan Weng,
BIOCELL 2020, 44(3), 353-361. https://doi.org/10.32604/biocell.2020.08955
Received 28 October 2019; Accepted 22 April 2020; Issue published 22 September 2020
Abstract
As a natural analog of resveratrol, piceatannol (Pic) exhibits good antioxidant and anti-inflammatory activities in
different disease models. However, the role of Pic in type 1 diabetes mouse model has not been reported yet. In this study, we
investigated the
in vivo effect of Pic in streptozotocin (STZ)-induced type 1 diabetic mice. Mice were injected with STZ to
establish the type 1 diabetes mellitus (T1DM) model. After stable hyperglycemia was achieved, mice were then orally treated
with Pic (40 mg/kg b.w., i.g.) for 30 days. The results indicated that Pic supplementation efficiently alleviated the typical
symptoms associated with T1DM, including body weight loss, polydipsia, hyperglycemia, and hypoinsulinemia. Pic
treatment also improved the glucose tolerance of STZ-induced diabetic mice. In addition, Pic supplementation markedly
decreased the expression of pro-inflammatory molecules TNF-α and IL-6, the expression of endoplasmic reticulum (ER)
stress markers GRP78 and CHOP, and the level of oxidative stress in T1DM mice. Moreover, Pic administration also
partly reversed the metabolic profiles of STZ-treated mice as detected by
1
H Nuclear Magnetic Resonance (NMR)-based
metabolomics. Our study suggested that the therapeutic potential of Pic in type 1 diabetes and the anti-diabetic effects of
Pic may be associated with its activities to suppress oxidative stress, inflammation, and ER stress.
Keywords
Cite This Article
ZHAO, M., GAO, P., TAO, L., WEN, J., WANG, L. et al. (2020). Piceatannol attenuates streptozotocin-induced type 1 diabetes in mice.
BIOCELL, 44(3), 353–361.
Citations