Heavy metals like cadmium, lead, and mercury in soil threaten crop growth and food safety. This review explores how modern technologies—genomics, transcriptomics,...
The image illustrates an intelligent driver monitoring framework for enhancing transportation safety. The system analyzes visual cues from the driver using deep...
Within a neuronal nucleus, contrasting DNA states symbolize the dual role of double-strand breaks in the brain. Transient, regulated breaks support activity-dependent...
Hong Kong and Guangzhou, China – September 2026 – Dr. Dany Xiang, Head of the Biomedical Journals Department at Tech Science Press (TSP), visited universities, hospitals, and research institutions...
Tech Science Press (TSP) is pleased to announce that five of its journals have been included in China’s 2025 list of the world’s leading science and technology journals. The five TSP journals...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Background: Congenital heart disease (CHD) remains the most common birth defect worldwide, with nearly one-quarter of affected infants requiring intervention in the first year of life. Despite global reductions in childhood mortality, 90% of children born with CHD in low- and middle-income countries (LMICs) lack access to essential cardiac care, contributing to significantly higher morbidity and mortality from CHD compared to high-income countries. The International Quality Improvement Collaborative for Congenital Heart Disease: Improving Care for Low-…
Background: Patent foramen ovale (PFO) is the most prevalent congenital cardiac anomaly and a key structural heart disease enabling paradoxical embolism, a leading mechanism of cryptogenic stroke. Over the past two decades, the management of PFO-associated stroke has evolved substantially from antithrombotic therapy alone to include percutaneous PFO closure. This systematic review aims to delineate the evolution of therapeutic strategies and clinical evidence in PFO-related stroke research, with particular emphasis on interventional and antithrombotic approaches. Methods:…
Background: This study aimed to evaluate the long-term prognosis and influencing factors in patients who underwent Fontan palliation. We specifically investigated the impact of demographic characteristics, preoperative clinical conditions, surgical techniques, and postoperative variables-particularly liver dysfunction markers such as the Model for End-Stage Liver Disease excluding the international normalized ratio (MELD-XI) score-on survival outcomes. Methods: We conducted a retrospective cohort study involving 322 patients who underwent the Fontan procedure. Comprehensive data on demographics, perioperative parameters, and…
Background: Infants undergoing surgery for congenital heart disease (CHD) are at high risk of developing gastrointestinal dysfunction (GID). Although abdominal near-infrared spectroscopy (NIRS) for monitoring tissue oxygen saturation (StO2) has shown clinical promise, its prognostic value remains to be fully elucidated. This study aimed to identify the risk factors associated with postoperative declines in abdominal StO2 and to evaluate its correlation with clinical outcomes. Methods: A total of 439 infants undergoing cardiac surgery with cardiopulmonary bypass between…
Background: Patent ductus arteriosus (PDA) can cause left-heart volume overload and functional mitral regurgitation (MR), although some patients have structural mitral abnormalities requiring repair. We compared MR and cardiac remodeling after isolated PDA closure and PDA closure combined with mitral valvuloplasty (MVP). Methods: This single-center retrospective study included 68 children treated between February 2013 and February 2025: isolated PDA transcatheter occlusion (IPTO, n = 34), isolated PDA surgical ligation (IPSL, n = 20), and PDA ligation…
Background: Cardiac magnetic resonance (CMR) imaging following transcatheter pulmonary valve replacement (TPVR) allows for the assessment of right ventricular (RV) volume. This study aimed to evaluate early- to mid-term findings after the procedure. Methods: A total of 21 patients with repaired tetralogy of Fallot who underwent TPVR were enrolled in the study. CMR data before and after the procedure were compared. The median interval between the procedure and the post-TPVR CMR was 9 months (range: 6–18…
Background: Balloon catheters are essential tools in congenital cardiac catheterization and are used for therapeutic balloon dilatation, anatomical balloon interrogation, and stent implantation. Clinical performance data for established devices have become increasingly important under the European Medical Device Regulation (MDR). We evaluated the procedural performance and safety of the Osypka VACS® (Valvuloplasty Catheter System; Osypka AG, Rheinfelden, Germany) II and VACS® III balloon catheters across a broad spectrum of congenital heart interventions. Methods: This retrospective single-center study…
Background: Fatigue is a prevalent clinical complaint in adolescence, but its determinants—particularly in congenital heart disease (CHD)—remain poorly understood. Objective: This study aimed to compare the severity and multidimensional profile of fatigue symptoms between adolescents with corrected CHD and school-based peers without reported chronic disease, and to evaluate the independent contributions of cardiac severity indices, echocardiographic parameters, and physical work capacity to fatigue severity. Methods: In a cross-sectional comparative study, 229 adolescents (11–17 years), including 154 with…
Background: Congenital heart disease (CHD) is characterized by a high incidence and low detection rate. The shortage of pediatric echocardiologists limits the routine ultrasound screening for CHD in many institutions. Deep learning has emerged as a promising tool to enhance the CHD diagnosis. This study aims to develop and evaluate a two-branch, two-stage intelligent algorithm (OBICnet) based on echocardiographic images to predict and classify common CHD in pediatric patients. Methods: A total of 8543 static color…
Background: Hypoattenuating leaflet thickening (HALT) is a reported complication following percutaneous pulmonary valve implantation (PPVI) Case description: A 32-year-old man with a history of repaired Tetralogy of Fallot (TOF) underwent PPVI for symptomatic severe pulmonary regurgitation (PR). The postoperative course was complicated by HALT diagnosed by computed tomography (CT) within 24 h of the procedure. Anticoagulation therapy was administered, and reassessment CT at 4 months showed resolution of HALT. Conclusion: HALT following PPVI is managed with anticoagulation
Growth Differentiation Factor 15 (GDF15) is a stress-responsive cytokine linking metabolism, inflammation and disease pathophysiology. In this review, we provide a comprehensive overview of its physiological and pathological functions, emphasising its relevance in various clinical contexts. We discuss the molecular mechanisms that regulate its expression and signalling, its role as a systemic biomarker of cellular and mitochondrial stress, and its function in maintaining metabolic homeostasis and in obesity-related disorders. In oncology, this cytokine plays a…
Cellular senescence is a durable stress response with double effects on cancer. Although stable cell-cycle arrest may initially restrict tumor growth, senescent tumor and stromal cells remain metabolically active and can remodel the tumor microenvironment through the senescence-associated secretory phenotype (SASP). This review synthesizes current evidence on therapy-induced and tumor-intrinsic senescence in prostate, bladder, and kidney cancers, focusing on molecular regulation and context-dependent SASP effects. We discuss how NF-κB, JAK/STAT3, cGAS-STING, and p38 MAPK regulate…
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine classically recognized as a central regulator of emergency myelopoiesis, promoting the expansion and differentiation of hematopoietic stem and progenitor cells (HSPCs) towards the myeloid lineage during infection and inflammation. In addition, GM-CSF enhances myeloid cell recruitment and activation, boosting antimicrobial functions and inflammatory responses. This coordinated capacity to enhance myelopoiesis while amplifying effector functions reflects a broader property of GM-CSF to functionally reprogram the hematopoietic system, not…
Background: Atopic dermatitis (AD) is associated with systemic immune dysregulation, but peripheral molecular markers that reliably reflect clinical severity remain insufficiently validated. Using complementary bulk and single-cell transcriptomics, we prioritized peripheral markers and evaluated them in independent clinical cohorts. Methods: Public peripheral blood mononuclear cell (PBMC) transcriptomes were analyzed by differential-expression analysis, weighted gene co-expression network analysis (WGCNA) with power-sensitivity and preservation assessments, immune-cell deconvolution, LASSO, and random forest. Descriptive single-gene receiver operating characteristic (ROC)…
Accumulating evidence suggests that the gut microbiota regulates cytokine gene expression through multiple epigenetic mechanisms that shape chromatin states in response to microbial metabolites. Alterations in the gut microbiota have been implicated in the pathogenesis of numerous inflammatory, autoimmune, and metabolic disorders. Key mediators including short-chain fatty acids, bile acids, and tryptophan derivatives modulate histone modifications and DNA methylation at cytokine gene loci, influencing the balance between pro-inflammatory and tolerogenic immune responses. Experimental evidence, including…
Osteoarthritis (OA) is increasingly recognized as a multifactorial disease in which metabolic dysfunction and chronic low-grade inflammation contribute to joint degeneration. Among the mediators involved, leptin has emerged as a key adipokine linking obesity, aging, and inflammatory processes to OA development and progression. However, despite growing evidence, its role remains incompletely understood, and a comprehensive framework integrating leptin-related mechanisms across different joint tissues is still lacking. This review provides an updated overview of the role…
Guest Editors: Van-Tu Nguyen; Ould el Moctar; Anh Dinh Le; Hemant J. Sagar Deadline: 30 September 2027
Guest Editors: Jin-Gyun Kim; Hee-Sun Choi; Seongji Han Deadline: 30 September 2027
Guest Editors: Hung-Yu Lin; Hsing-Ju Wu Deadline: 31 May 2027
Guest Editors: Carlos Vargas-Salgado; Dácil Diaz-Bello Deadline: 30 April 2027
Guest Editors: Leonardo Di G. Sigalotti; Carlos A. Vargas; Carlos E. Alvarado-Rodríguez Deadline: 30 April 2027
Guest Editors: Sabrina Tosi; Annabelle Lewis Deadline: 30 April 2027
Guest Editors: Antonella Petrillo; Fabio De Felice Deadline: 15 April 2027
Guest Editors: Wenlong Sun; Mengyao Li Deadline: 31 March 2027
Guest Editors: Wenbing Zhao; Pan Wang Deadline: 31 March 2027
Guest Editors: Wenfeng Zheng; Choon Kit Chan; Kyungtae Kang; Chao Liu Deadline: 31 March 2027
Guest Editors: Joanna Zawitkowska; Małgorzata Mitura-Lesiuk; Maciej Dubaj Deadline: 28 February 2027
Guest Editors: Wenfeng Zheng; Lirong Yin; Shan Liu Deadline: 15 February 2027
Guest Editors: Wei-Chiang Hong; Yi Liang; Ming-Wei Li; Zhong-Yi Yang Deadline: 15 February 2027
Guest Editors: Jungpil Shin; Yong Seok Hwang Deadline: 31 January 2027
Guest Editors: Denise Mafra; Jessyca Sousa de Brito Deadline: 31 January 2027
Guest Editors: Qi Chen; Yunhui Tang Deadline: 31 December 2026






