Heavy metals like cadmium, lead, and mercury in soil threaten crop growth and food safety. This review explores how modern technologies—genomics, transcriptomics,...
The image illustrates an intelligent driver monitoring framework for enhancing transportation safety. The system analyzes visual cues from the driver using deep...
Within a neuronal nucleus, contrasting DNA states symbolize the dual role of double-strand breaks in the brain. Transient, regulated breaks support activity-dependent...
Hong Kong and Guangzhou, China – September 2026 – Dr. Dany Xiang, Head of the Biomedical Journals Department at Tech Science Press (TSP), visited universities, hospitals, and research institutions...
Tech Science Press (TSP) is pleased to announce that five of its journals have been included in China’s 2025 list of the world’s leading science and technology journals. The five TSP journals...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Growth Differentiation Factor 15 (GDF15) is a stress-responsive cytokine linking metabolism, inflammation and disease pathophysiology. In this review, we provide a comprehensive overview of its physiological and pathological functions, emphasising its relevance in various clinical contexts. We discuss the molecular mechanisms that regulate its expression and signalling, its role as a systemic biomarker of cellular and mitochondrial stress, and its function in maintaining metabolic homeostasis and in obesity-related disorders. In oncology, this cytokine plays a…
Cellular senescence is a durable stress response with double effects on cancer. Although stable cell-cycle arrest may initially restrict tumor growth, senescent tumor and stromal cells remain metabolically active and can remodel the tumor microenvironment through the senescence-associated secretory phenotype (SASP). This review synthesizes current evidence on therapy-induced and tumor-intrinsic senescence in prostate, bladder, and kidney cancers, focusing on molecular regulation and context-dependent SASP effects. We discuss how NF-κB, JAK/STAT3, cGAS-STING, and p38 MAPK regulate…
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine classically recognized as a central regulator of emergency myelopoiesis, promoting the expansion and differentiation of hematopoietic stem and progenitor cells (HSPCs) towards the myeloid lineage during infection and inflammation. In addition, GM-CSF enhances myeloid cell recruitment and activation, boosting antimicrobial functions and inflammatory responses. This coordinated capacity to enhance myelopoiesis while amplifying effector functions reflects a broader property of GM-CSF to functionally reprogram the hematopoietic system, not…
Background: Atopic dermatitis (AD) is associated with systemic immune dysregulation, but peripheral molecular markers that reliably reflect clinical severity remain insufficiently validated. Using complementary bulk and single-cell transcriptomics, we prioritized peripheral markers and evaluated them in independent clinical cohorts. Methods: Public peripheral blood mononuclear cell (PBMC) transcriptomes were analyzed by differential-expression analysis, weighted gene co-expression network analysis (WGCNA) with power-sensitivity and preservation assessments, immune-cell deconvolution, LASSO, and random forest. Descriptive single-gene receiver operating characteristic (ROC)…
Accumulating evidence suggests that the gut microbiota regulates cytokine gene expression through multiple epigenetic mechanisms that shape chromatin states in response to microbial metabolites. Alterations in the gut microbiota have been implicated in the pathogenesis of numerous inflammatory, autoimmune, and metabolic disorders. Key mediators including short-chain fatty acids, bile acids, and tryptophan derivatives modulate histone modifications and DNA methylation at cytokine gene loci, influencing the balance between pro-inflammatory and tolerogenic immune responses. Experimental evidence, including…
Osteoarthritis (OA) is increasingly recognized as a multifactorial disease in which metabolic dysfunction and chronic low-grade inflammation contribute to joint degeneration. Among the mediators involved, leptin has emerged as a key adipokine linking obesity, aging, and inflammatory processes to OA development and progression. However, despite growing evidence, its role remains incompletely understood, and a comprehensive framework integrating leptin-related mechanisms across different joint tissues is still lacking. This review provides an updated overview of the role…
Short-chain fatty acids (SCFAs) are increasingly recognized as active modulators of tumor immunity. However, organizing evidence only by tumor type, metabolite species, or individual pathway may not fully explain their context-dependent effects. This Review clarifies how SCFAs regulate tumor immunity by remodeling cytokine and chemokine networks within the tumor microenvironment and defines the contextual factors that determine whether these effects support or restrain antitumor responses. We organize SCFA-driven effects into four functional cytokine domains: pro-inflammatory,…
Interleukin-18 (IL-18) is a pleiotropic IL-1-family cytokine whose clinical relevance depends strongly on context. A central reason is that IL-18 activity is constrained by interleukin-18 binding protein (IL-18BP), a high-affinity endogenous antagonist that limits the free, bioactive cytokine fraction. This review re-examines the IL-18/IL-18BP axis across a clinical gradient from barrier dysfunction and allergic disease, through systemic autoimmunity, to Still disease, macrophage activation syndrome, hemophagocytic lymphohistiocytosis, and monogenic IL-18opathies. We emphasize that total IL-18 elevation…
Background: Early and accurate differential diagnosis of rheumatoid arthritis (RA) remains challenging, particularly in patients with seronegative or non-specific inflammatory arthritides. Because cytokines and chemokines play central roles in immune activation and leukocyte trafficking, we investigated whether serum cytokine and chemokine profiles could discriminate RA from non-rheumatoid arthritides (NRA) and healthy controls (HCs). Methods: One hundred and fifty-seven RA patients (104 anti-cyclic citrullinated peptide antibody (ACPA)-positive and 53 ACPA-negative patients), 33 NRA patients and 86…
Background: Crohn’s disease (CD) is a chronic inflammatory disorder resulting from the interaction between genetic susceptibility, environmental factors, intestinal microbiota, and dysregulated immune responses. Despite major advances, the precise mechanisms underlying disease development remain incompletely understood. This study aimed to evaluate the proportions of Th17 and regulatory T (Treg) cells, as well as serum cytokine levels, in the peripheral blood of patients with CD. Methods: We enrolled 46 patients with active CD (median age: 31.5…
This narrative review summarises epidemiological associations and evaluates proposed mechanisms linking gout and hyperuricaemia with cardiovascular dysfunction and remodelling. Gout is a crystal arthropathy that is increasingly recognised as also carrying systemic cardio-inflammatory features. Hyperuricaemia and monosodium urate (MSU) crystals trigger Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) and NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome signalling, driving IL-1β, IL-6, and TNF-α release together with xanthine oxidase (XO)–derived oxidative stress. Experimental studies in hyperuricaemia…
Cancer and fibrosis are two pathological conditions that although of different clinical appearance have several shared characteristics, most likely because of a common etiology (for example in case of Silica). Here, we present a comprehensive review of the literature, with respect to Crystalline Silica, a known carcinogenic and fibrogenic agent, aiming to highlight common denominators between both diseases, as well as their differences. The results from various studies point to the involvement of the immune…
This study investigates how tip-clearance variation affects blade deformation, aerodynamic performance, near-tip flow structures, and irreversible energy loss in a transonic compressor. NASA Rotor 37 is used as the research model, and a two-way fluid–structure interaction framework coupled with entropy-generation analysis is developed to resolve the interplay between structural deformation and tip-leakage flow. At the respective peak-efficiency operating points, increasing the nominal tip clearance from 1.0δ to 3.0δ produces little change in the chordwise-averaged radial…
This study develops a sequential numerical modelling framework to elucidate the transient evolution of liquid hydrogen (LH2) leakage, pool evaporation, hydrogen dispersion, and post-ignition thermal hazards in a representative semi-open railway station. The framework couples a source-term integral model for LH2 pool evaporation with computational fluid dynamics (CFD), in which the time-dependent liquid-pool radius and evaporation mass flow rate are introduced as transient inlet conditions through a user-defined function. The Realizable k-ε turbulence model and species transport…
The influence of nozzle orifice number on the jet dynamics and rock-breaking performance of multi-orifice abrasive water jets (MOAWJ) is systematically examined for precision drilling in pumped storage power station construction. A VOF-DPM (Volume of Fluid–Discrete Phase Model) two-way coupling framework is first employed to characterize the flow-field structure, velocity distribution, and spatial evolution of abrasive particles for different orifice configurations. The resulting jet characteristics are then used as initial conditions in an SPH-FEM (Smoothed…
This study develops and systematically evaluates a hierarchical tree-shaped finned-tube heat exchanger designed to enhance hydrogen absorption in porous metal-hydride (MH) storage reactors. The proposed architecture combines geometrically nested primary, secondary, and tertiary tubes with branched fins to redistribute cooling capacity from the reactor core towards peripheral regions where localized reaction dead zones develop. A validated two-dimensional transient model, incorporating Darcy-law porous-media flow, heat transfer between the MH bed and the aluminium heat-exchanger structure, and LaNi5…
Guest Editors: Van-Tu Nguyen; Ould el Moctar; Anh Dinh Le; Hemant J. Sagar Deadline: 30 September 2027
Guest Editors: Jin-Gyun Kim; Hee-Sun Choi; Seongji Han Deadline: 30 September 2027
Guest Editors: Hung-Yu Lin; Hsing-Ju Wu Deadline: 31 May 2027
Guest Editors: Carlos Vargas-Salgado; Dácil Diaz-Bello Deadline: 30 April 2027
Guest Editors: Leonardo Di G. Sigalotti; Carlos A. Vargas; Carlos E. Alvarado-Rodríguez Deadline: 30 April 2027
Guest Editors: Sabrina Tosi; Annabelle Lewis Deadline: 30 April 2027
Guest Editors: Antonella Petrillo; Fabio De Felice Deadline: 15 April 2027
Guest Editors: Wenlong Sun; Mengyao Li Deadline: 31 March 2027
Guest Editors: Wenbing Zhao; Pan Wang Deadline: 31 March 2027
Guest Editors: Wenfeng Zheng; Choon Kit Chan; Kyungtae Kang; Chao Liu Deadline: 31 March 2027
Guest Editors: Joanna Zawitkowska; Małgorzata Mitura-Lesiuk; Maciej Dubaj Deadline: 28 February 2027
Guest Editors: Wenfeng Zheng; Lirong Yin; Shan Liu Deadline: 15 February 2027
Guest Editors: Wei-Chiang Hong; Yi Liang; Ming-Wei Li; Zhong-Yi Yang Deadline: 15 February 2027
Guest Editors: Jungpil Shin; Yong Seok Hwang Deadline: 31 January 2027
Guest Editors: Denise Mafra; Jessyca Sousa de Brito Deadline: 31 January 2027
Guest Editors: Qi Chen; Yunhui Tang Deadline: 31 December 2026






