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Computers, Materials & Continua
REVIEW

Multiscale Numerical Simulation of Dynamic Damage and Fracture in Metallic Materials: A Review

This paper provides a comprehensive review of recent advances in multi-scale modeling for simulating dynamic damage and fracture in metallic materials,...

Computers, Materials & Continua
REVIEW

3D Single Object Tracking in Point Clouds: A Review

3D single object tracking (SOT) based on point clouds is a fundamental task for environmental perception in autonomous driving and dynamic scene understanding...

Computers, Materials & Continua
REVIEW

Applications of Machine Learning in Polymer Materials: Property Prediction, Material Design, and Systematic Processes

This paper reviews the research progress and application prospects of machine learning technologies in the field of polymer materials. Currently, machine...

Journal of Polymer Materials
REVIEW

Multifunctional Carbonaceous Nanoreinforced Polymeric Nanofibers—Bridging Fundamental Aspects to Technological Resolves

Purpose of this novel review article is to unfold the current scientific worth of high performance polymer nanocomposite nanofibers, owing to growing...

Journal of Polymer Materials
REVIEW

Biobased Biodegradable Plastics for Food Packaging: Recent Progress, Feasibility and Limitations

Biobased biodegradable plastics have gained increasing attention as sustainable alternatives to petroleum-based materials in food packaging, offering...

Journal of Renewable Materials
REVIEW

Enhancements in Oil Palm Fiber for Composite Material Development

Oil palm fiber is a natural fiber derived from agricultural biomass and has gained significant attention as an alternative reinforcement material in composite...

Oncology Research
REVIEW

Understanding the Tumor Microenvironmental Mechanisms Driving Immunotherapy Resistance in Colorectal Cancer Liver Metastases

Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality...

Oncology Research
REVIEW

Epigenetics of Malignant Melanoma: Mechanisms, Diagnostic Approaches and Therapeutic Applications

Malignant melanoma (MM) is a highly aggressive skin cancer known for its rapid progression, potential for metastasis, and resistance to treatment. Despite...

Oncology Research
REVIEW

Ferroptosis as a Translational Axis in Small Cell Lung Cancer: A Systematic Review of Redox Pathways and Precision Oncology Prospects

Background: An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer (SCLC)....

Oncology Research
REVIEW

Novel Immunotherapeutic Approaches for Patients with Head and Neck Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and typically involves the head and neck. Systemic therapy is often...

Oncology Research
ARTICLE

Serum Biomarkers in Bladder Cancer: NMR Metabolomics for Identification and Monitoring during Platinum-Based Therapy

Objectives: To date, predictive and prognostic biomarkers for Bladder Cancer (BC) remain lacking. Existing literature underscores the potential of metabolomics...

Computers, Materials & Continua
REVIEW

A Survey on Multimodal Emotion Recognition: Methods, Datasets, and Future Directions

Multimodal emotion recognition has emerged as a key research area for enabling human-centered artificial intelligence, supported by the rapid progress...

Computers, Materials & Continua
ARTICLE

Large Language Model-Enabled Constitutive Modeling for Rate-Dependent Plasticity and Automatic UMAT Subroutine Generation

In materials science and engineering design, high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical...

Computers, Materials & Continua
ARTICLE

A Materials Discovery Method Considering the Trade-Off Phenomenon in Machine Learning Prediction Capabilities between Interpolation and Extrapolation: Case Study on Multi-Objective Mg-Zn-Al Alloy Design

The exploration of high-performance materials presents a fundamental challenge in materials science, particularly in predicting properties for materials...

Computers, Materials & Continua
ARTICLE

LEAF: A Lightweight Edge Agent Framework with Expert SLMs for the Industrial Internet of Things

Deploying Large Language Model (LLM)-based agents in the Industrial Internet of Things (IIoT) presents significant challenges, including high latency...

Fluid Dynamics & Materials Processing
ARTICLE

Numerical Assessment of Novel Windbreak Designs for Flow Control and Heat Transfer Enhancement in Natural Draft Dry Cooling Towers

This study aims to mitigate crosswind-induced performance degradation in Natural Draft Dry Cooling Towers used in power plants by developing and assessing...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Fluid Dynamics & Materials Processing
Special Issue

Fluid and Thermal Dynamics in the Development of Unconventional Resources III

Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...

Computer Modeling in Engineering & Sciences
Special Issue

Machine Learning and Deep Learning-Based Pattern Recognition

In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...

Computer Modeling in Engineering & Sciences
Special Issue

Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges

This special issue, “Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges,” showcases the transformative power of...

Revue Internationale de Géomatique
Special Issue

Advancements in Geospatial Methods and Technologies for Sustainable Built Environment and Engineering

This theme captures the essence of advanced technologies (AI, machine learning, big data), modern applications (climate change, smart cities, health research),...

Computers, Materials & Continua
REVIEW

Multiscale Numerical Simulation of Dynamic Damage and Fracture in Metallic Materials: A Review

This paper provides a comprehensive review of recent advances in multi-scale modeling for simulating dynamic damage and fracture in metallic materials,...

Computers, Materials & Continua
REVIEW

3D Single Object Tracking in Point Clouds: A Review

3D single object tracking (SOT) based on point clouds is a fundamental task for environmental perception in autonomous driving and dynamic scene understanding...

Computers, Materials & Continua
REVIEW

Applications of Machine Learning in Polymer Materials: Property Prediction, Material Design, and Systematic Processes

This paper reviews the research progress and application prospects of machine learning technologies in the field of polymer materials. Currently, machine...

Journal of Polymer Materials
REVIEW

Multifunctional Carbonaceous Nanoreinforced Polymeric Nanofibers—Bridging Fundamental Aspects to Technological Resolves

Purpose of this novel review article is to unfold the current scientific worth of high performance polymer nanocomposite nanofibers, owing to growing...

Journal of Polymer Materials
REVIEW

Biobased Biodegradable Plastics for Food Packaging: Recent Progress, Feasibility and Limitations

Biobased biodegradable plastics have gained increasing attention as sustainable alternatives to petroleum-based materials in food packaging, offering...

Journal of Renewable Materials
REVIEW

Enhancements in Oil Palm Fiber for Composite Material Development

Oil palm fiber is a natural fiber derived from agricultural biomass and has gained significant attention as an alternative reinforcement material in composite...

Oncology Research
REVIEW

Understanding the Tumor Microenvironmental Mechanisms Driving Immunotherapy Resistance in Colorectal Cancer Liver Metastases

Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality...

Oncology Research
REVIEW

Epigenetics of Malignant Melanoma: Mechanisms, Diagnostic Approaches and Therapeutic Applications

Malignant melanoma (MM) is a highly aggressive skin cancer known for its rapid progression, potential for metastasis, and resistance to treatment. Despite...

Oncology Research
REVIEW

Ferroptosis as a Translational Axis in Small Cell Lung Cancer: A Systematic Review of Redox Pathways and Precision Oncology Prospects

Background: An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer (SCLC)....

Oncology Research
REVIEW

Novel Immunotherapeutic Approaches for Patients with Head and Neck Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and typically involves the head and neck. Systemic therapy is often...

Oncology Research
ARTICLE

Serum Biomarkers in Bladder Cancer: NMR Metabolomics for Identification and Monitoring during Platinum-Based Therapy

Objectives: To date, predictive and prognostic biomarkers for Bladder Cancer (BC) remain lacking. Existing literature underscores the potential of metabolomics...

Computers, Materials & Continua
REVIEW

A Survey on Multimodal Emotion Recognition: Methods, Datasets, and Future Directions

Multimodal emotion recognition has emerged as a key research area for enabling human-centered artificial intelligence, supported by the rapid progress...

Computers, Materials & Continua
ARTICLE

Large Language Model-Enabled Constitutive Modeling for Rate-Dependent Plasticity and Automatic UMAT Subroutine Generation

In materials science and engineering design, high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical...

Computers, Materials & Continua
ARTICLE

A Materials Discovery Method Considering the Trade-Off Phenomenon in Machine Learning Prediction Capabilities between Interpolation and Extrapolation: Case Study on Multi-Objective Mg-Zn-Al Alloy Design

The exploration of high-performance materials presents a fundamental challenge in materials science, particularly in predicting properties for materials...

Computers, Materials & Continua
ARTICLE

LEAF: A Lightweight Edge Agent Framework with Expert SLMs for the Industrial Internet of Things

Deploying Large Language Model (LLM)-based agents in the Industrial Internet of Things (IIoT) presents significant challenges, including high latency...

Fluid Dynamics & Materials Processing
ARTICLE

Numerical Assessment of Novel Windbreak Designs for Flow Control and Heat Transfer Enhancement in Natural Draft Dry Cooling Towers

This study aims to mitigate crosswind-induced performance degradation in Natural Draft Dry Cooling Towers used in power plants by developing and assessing...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Fluid Dynamics & Materials Processing
Special Issue

Fluid and Thermal Dynamics in the Development of Unconventional Resources III

Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...

Computer Modeling in Engineering & Sciences
Special Issue

Machine Learning and Deep Learning-Based Pattern Recognition

In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...

Computer Modeling in Engineering & Sciences
Special Issue

Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges

This special issue, “Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges,” showcases the transformative power of...

Revue Internationale de Géomatique
Special Issue

Advancements in Geospatial Methods and Technologies for Sustainable Built Environment and Engineering

This theme captures the essence of advanced technologies (AI, machine learning, big data), modern applications (climate change, smart cities, health research),...

ETS1 Regulates Endothelial AQP1 Expression via Interaction with MEF2C in Endothelial Cells

Background: Aquaporin 1 (AQP1) plays a key role in myocardial ischemia-reperfusion (I/R) injury. This study aimed to elucidate the mechanisms by which erythroblast transformation-specific 1 (ETS1) and myocyte enhancer factor 2C (MEF2C) regulated AQP1 transcription. Methods: Human umbilical vein endothelial cells (HUVECs) and rats with coronary heart disease were employed for in vitro and in vivo experiments, respectively. Expressions of ETS1, MEF2C, and AQP1 were analyzed by western blotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Chromatin…

BIOCELL
Article

Research on the Mechanism of Gallic Acid Inhibiting Ferroptosis and Delaying IgA Nephropathy by Regulating the MAPK Signaling Pathway through DUSP1

Objectives: IgA nephropathy (IgAN) is a common primary glomerulonephritis with limited treatment options. Gallic acid (GA) has demonstrated renal protective effects, but its precise mechanisms against IgAN remain incompletely elucidated. This study aims to reveal the molecular mechanism by which GA exerts a renal protective effect on IgAN. Methods: Transcriptomics and network pharmacology were combined in an integrative manner. The GSE175759 dataset’s differentially expressed genes (DEGs) were filtered out. SwissTargetPrediction and Traditional Chinese Medicine Systems…

BIOCELL
Review

Research Advances and Therapeutic Potential of Gut Microbiota in Metabolic Diseases

The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis. Accumulating evidence has demonstrated that dysbiosis of the gut microbiota is closely associated with metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). These alterations affect energy harvest, bile acid and short-chain fatty acid metabolism, intestinal barrier integrity, and low-grade inflammation, thereby contributing to insulin resistance and ectopic fat accumulation. In this narrative review, we summarize current…

BIOCELL
Article

SOX11 Alleviates Osteoarthritis through Reducing Mitochondrial Dysfunction and Ferroptosis via Binding to the Promoter of NOX4

Objectives: Mitochondrial dysfunction and ferroptosis play crucial roles in osteoarthritis (OA), but the mechanisms remain unclear. This study aims to investigate the mechanism of sex-determining region Y-box transcription factor (SOX) 11/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) axis-mediated mitochondrial dysfunction and ferroptosis in OA. Methods: Destabilization of the medial meniscus (DMM) induced knee OA in mice. Chondrocytes were stimulated with IL-1β. Ferroptosis and mitochondrial function-related indicators were detected by immunofluorescence, 5,5^′,6,6^′-Tetrachloro-1,1^′,3,3^′-tetraethyl-imidacarbocyanine iodide (JC-1) staining, flow…

BIOCELL
Review

Molecular Mechanisms and Signaling Pathways of Myocardial Ischemia: A Multidimensional Analysis from Energy Metabolism to Cell Death

Myocardial ischemia, a core pathological process underlying diverse cardiovascular diseases such as coronary artery disease, poses a severe threat to global human health by frequently leading to acute myocardial infarction, heart failure, and even sudden cardiac death. A comprehensive understanding of its intricate underlying pathogenic mechanisms is not only crucial for developing effective therapeutic strategies but also essential for accelerating the translation of basic research findings into clinical practice. However, the complex regulatory networks that…

BIOCELL
Protocol

Flow Cytometry Study of Immune Cell Subpopulations from the Mouse Vertebral Bone Marrow and Intervertebral Disc Following Endplate Microfracture

Objective: Although endplate (EP) injury may cause intervertebral disc (IVD) degeneration and Modic changes (MCs) in the vertebral bone marrow (VBM), EP injury-induced synchronous cellular reactions and their crosstalk in the IVD and VBM remain unclear. This protocol-based study aimed to streamline and optimize the methods of tissue harvest and cell preparation for flow cytometry (FCM) analysis of T-cell and macrophage subpopulations in both VBM and IVD adjacent to the surgically induced EP microfracture in…

BIOCELL
Article

KDM6B Regulates the Tumor Microenvironment and Promotes EMT via the PI3K/AKT/mTOR Signaling in Differentiated Thyroid Cancer

Objectives: The tumor microenvironment and epithelial-mesenchymal transition (EMT) are closely linked to the progression of differentiated thyroid cancer (DTC). However, the functional mechanisms of lysine-specific demethylase 6B (KDM6B) in carcinogenesis remain incompletely understood. This study aims to clarify whether KDM6B affects DTC progression and EMT through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/AKT/mTOR) pathway, providing a potential target for clinical treatment of DTC. Methods: Tissue samples from DTC patients (n = 39)…

BIOCELL
Review

Targeting Inflammation in Coronary Artery

Atherosclerosis (AS) is a key contributor to ischemic heart disease, resulting in significant cardiovascular (CV) morbidity and mortality worldwide. Despite advancements in managing conventional risk factors, including the utilization of statins, recurrent adverse cardiovascular events remain prevalent, emphasizing the need for novel therapeutic strategies. This review explores the critical role of inflammation in the pathogenesis of coronary artery disease (CAD) and highlights potential atheroprotective approaches targeting inflammatory pathways. We discuss the multifaceted interplay between immune…

BIOCELL
Review

Targeting Protein Arginine Deiminases in Rheumatoid Arthritis: Pathophysiology and Therapeutic Progress

Protein arginine deiminases (PADs) are key enzymes in the development of rheumatoid arthritis (RA), catalyzing the conversion of arginine to citrulline in a process called citrullination. This post-translational modification is crucial to RA pathogenesis as it creates neo-antigens that trigger the production of anti-citrullinated protein antibodies (ACPAs). These ACPAs are highly specific to RA and often appear before clinical symptoms, making them valuable biomarkers for diagnosis and prognosis. Beyond ACPA production, PADs, particularly PAD4, play…

BIOCELL
Review

The Therapeutic Potential of iNKT Cells in the Treatment of Ovarian Cancer

Ovarian cancer (OC) remains the most lethal gynecological malignancy, and it is characterized by high heterogeneity, early metastatic dissemination, and frequent recurrence within 12–18 months after primary therapy. Despite progress in clinical management and drug development, the mortality rate remains high, and the biological drivers of OC aggressiveness are not fully understood. A major contributor to therapeutic resistance and disease progression is the ovarian tumor microenvironment (TME), which supports tumor growth and immune evasion. Its…

Canadian Journal of Urology
EDITORIAL

Ten Years of Progress in Advanced Prostate Cancer at the AUA

This article has no abstract.

Canadian Journal of Urology
LEGENDS IN UROLOGY

Legends in Urology

This article has no abstract.

Canadian Journal of Urology
REVIEW

Can AI and predictive models accurately predict stone-free status? a systematic review and meta-analysis

Objectives: The emergence of artificial intelligence (AI) and predictive modeling offers prospects for clinical, anatomical, and imaging factor combination, like radiomics, to help with stone-free status (SFS) estimation and peroperative decision-making. The goal of this study was, therefore, to define the present performance range, determine sources of heterogeneity, and determine methodological practices permitting reliable implementation by varied circumstances. Methods: We searched six bibliographic databases through 19 September 2025. Studies deriving or validating AI/predictive models for…

Canadian Journal of Urology
article

Proximal/Distal ureteral diameter ratio as a predictor of spontaneous passage in <10 mm ureteral stones

Background: Ureteral stones are a common cause of acute renal colic, and while most small stones pass spontaneously, reliable predictors of passage are needed to optimize patient selection for conservative management. This study aims to evaluate the role of radiologic, clinical and laboratory parameters—particularly the proximal/distal (P/D) ureteral diameter ratio—in predicting spontaneous passage of <10 mm ureteral stones. Materials and Methods: This retrospective cohort study included 277 patients diagnosed with ureteral calculi <10 mm on non-contrast…

Canadian Journal of Urology
article

Analysis of risk factors for MRI-invisible prostate cancer—the significance of AGGF1 immunohistochemical detection and PSAD

Objectives: Patients with a multi-parameter magnetic resonance imaging (mpMRI) prostate imaging report and data system (PI-RADS) score ≤ 3, but with clinically significant prostate cancer (CSPCa) detected by biopsy, are termed MRI-Invisible prostate cancer (MRI(-)PCa). This study aims to explore risk factors for MRI(-)PCa and identify immunohistochemical indicators with predictive significance. Methods: A retrospective analysis was conducted on 376 patients with PI-RADS score ≤ 3 who underwent 24-needle systematic prostate biopsy at Beijing Friendship Hospital,…

Canadian Journal of Urology
article

Evaluating pain management strategies following hypospadias repair: a survey of pediatric urologists

Background: Pediatric opioid use has been associated with serious adverse effects, including persistent use and overdose. Recent studies have shown that opioid needs may be minimal following outpatient pediatric urologic surgery. Post-operative pain regimens following pediatric penile surgery are not standardized. This study aimed to identify current opioid prescribing practices following hypospadias repair. Methods: An online survey was administered to members of the Societies for Pediatric Urology, including eight questions surrounding physician demographics, hypospadias repair…