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  • Open Access

    ARTICLE

    Identification of prognostic molecular subtypes and model based on CD8+ T cells for lung adenocarcinoma

    HONGMIN CAO1,#,*, YING XUE2,#, FEI WANG1, GUANGYAO LI1, YULAN ZHEN1, JINGWEN GUO1

    BIOCELL, Vol.48, No.3, pp. 473-490, 2024, DOI:10.32604/biocell.2024.048946

    Abstract Background: Cytotoxic T lymphocytes (CD8+ T) cells function critically in mediating anti-tumor immune response in cancer patients. Characterizing the specific functions of CD8+ T cells in lung adenocarcinoma (LUAD) could help better understand local anti-tumor immune responses and estimate the effect of immunotherapy. Methods: Gens related to CD8+ T cells were identified by cluster analysis based on the single-cell sequencing data of three LUAD tissues and their paired normal tissues. Weighted gene co-expression network analysis (WGCNA), consensus clustering, differential expression analysis, least absolute shrinkage and selection operator (LASSO) and Cox regression analysis were conducted to classify molecular subtypes for LUAD… More > Graphic Abstract

    Identification of prognostic molecular subtypes and model based on CD8+ T cells for lung adenocarcinoma

  • Open Access

    REVIEW

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

    CAIJUAN LIU, XINGHAO LI, YUXUAN WU, JINHUI YANG, MENGHAN WANG, YUNQI MA*

    BIOCELL, Vol.48, No.3, pp. 387-401, 2024, DOI:10.32604/biocell.2024.048791

    Abstract Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, is the most malignant and still has no cure. However, the novel role of long non-coding RNAs (lncRNAs) in the pathogenesis of glioblastoma is attracting extensive attention. LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins. Unlike small non-coding RNAs, such as microRNAs (miRNAs), lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA, RNA, and proteins and perform multiple regulatory functions. LncRNAs act as molecular sponges, absorbing and sequestering other biomolecules, particularly miRNAs, thereby preventing these… More > Graphic Abstract

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

  • Open Access

    REVIEW

    How aging affects bone health via the intestinal micro-environment

    HUAN HU1,2,*, YUE HUANG1, FANGZHOU LIU1, QIAN WANG1,2, YANZI YAO3,*

    BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311

    Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on… More >

  • Open Access

    ARTICLE

    Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma

    YANAN MA1, SHANSHAN WANG2,*, HUIGUO DING1,*

    BIOCELL, Vol.48, No.3, pp. 463-471, 2024, DOI:10.32604/biocell.2024.048244

    Abstract Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality worldwide. Although cystathionine-gamma-lyase (CSE) plays an important role in the development of multiple tumors, the clinical implication and potential mechanisms of CSE in HCC development remain elusive. Methods: In our study, the CSE expression in HCC was analyzed in Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets and further confirmed by RT-qPCR and immunohistochemistry assays in HCC samples. Furthermore, the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated in HCC patients. Finally, the… More >

  • Open Access

    ARTICLE

    SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma

    JIYU WANG1,#, LIUYING YI2,#, KEKE HUANG1, YANGYANG WANG1, HUIPING WANG1, ZHIMIN ZHAI1,*

    BIOCELL, Vol.48, No.3, pp. 453-462, 2024, DOI:10.32604/biocell.2024.047871

    Abstract Background: The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma (r/r B-NHL) is resistance to current therapies, and therapy-induced senescence (TIS) stands out as a crucial mechanism contributing to tumor drug resistance. Here, we analyzed SENEX/Rho GTPase Activating Protein 18 (ARHGAP18) expression and prognostic significance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients, investigating its target in B-NHL cell senescence and the effect of combining specific inhibitors on apoptosis resistance in B-NHL-TIS cells. Methods: Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector (Sh-SENEX) and the empty vector negative (NC) to… More >

  • Open Access

    REVIEW

    Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

    LISHA MA1,#, WANQI SHAO1,#, WEILI ZHU2,*

    BIOCELL, Vol.48, No.3, pp. 379-386, 2024, DOI:10.32604/biocell.2024.047812

    Abstract The morbidity rate of ovarian cancer, a malignant tumour in gynaecological tumours, is rising, and it is considered to be the most lethal cancer. The majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and specific diagnostic indicators. Surgical excision of the lesions, along with chemotherapy, is the conventional treatment for ovarian cancer; however, resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently arises. Improving the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identification… More >

  • Open Access

    ARTICLE

    CircR-ZC3HC1 mediates MiR-384-5p/SIRT1 axis to promote neuronal autophagy and relieves ischemic stroke

    MIN SHEN1,2, XIAOMAN XU1,2, GUANGLING SUN1, LIANGZHU WANG1, TAO YING1, HANG SU1, WEI WANG1, QINGHUA CAO1,*, ZHEZHE SUN1,*

    BIOCELL, Vol.48, No.3, pp. 491-499, 2024, DOI:10.32604/biocell.2023.047640

    Abstract Objective: Circular RNAs (circRNAs) have been shown to involve in pathological processes of ischemic stroke (IS), including autophagy. This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms. Methods: Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected. Hippocampal neurons were treated with oxygen and glucose deprivation (OGD) to establish IS in vitro model. The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope. Cell apoptosis rate… More >

  • Open Access

    ARTICLE

    MiR-30a-5p alleviates LPS-induced HPMEC injury through regulation of autophagy via Beclin-1

    RAN PAN1,#, JIAYAN MAO2,#, YUELIANG ZHENG3, WEI CHEN2, JUNPING GUO1,*, LIJUN WANG3,*

    BIOCELL, Vol.48, No.3, pp. 431-441, 2024, DOI:10.32604/biocell.2023.046484

    Abstract Background: Sepsis, a type of systemic disease, can impact nearly all organs, tissues and cells. Among them, endothelial cells are amongst the first to be affected and respond to the insult. In this study, we investigated the protective effects of microRNA-30a-5p (miR-30a-5p) on human pulmonary microvascular endothelial cells (HPMECs) treated with lipolysaccharide (LPS). Methods: An in vitro model of sepsis was established in HPMECs with the use of LPS. Transfecting with different tools (mimetic and inhibitor) to modify miR-30a-5p expression. Cell viability, proliferation and apoptosis were detected by the CCK-8 assay, the EdU kit and fluorescence staining, respectively. The autophagy-related… More >

  • Open Access

    REVIEW

    The heterogeneity of tumor-associated macrophages and strategies to target it

    HAO LV1, BO ZHU1,2, DEGAO CHEN1,2,*

    BIOCELL, Vol.48, No.3, pp. 363-378, 2024, DOI:10.32604/biocell.2023.046367

    Abstract Tumor-associated macrophages (TAMs) are emerging as targets for tumor therapy because of their primary role in promoting tumor progression. Several studies have been conducted to target TAMs by reducing their infiltration, depleting their numbers, and reversing their phenotypes to suppress tumor progression, leading to the development of drugs in preclinical and clinical trials. However, the heterogeneous characteristics of TAMs, including their ontogenetic and functional heterogeneity, limit their targeting. Therefore, in-depth exploration of the heterogeneity of TAMs, combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor treatment. This review focuses on the heterogeneous ontogeny and… More >

  • Open Access

    ARTICLE

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

    SHAN OU#, YUN XU#, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI*, JIE YAO*

    BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178

    Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a series of experiments, including the… More > Graphic Abstract

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

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