Open Access

REVIEW

Regulation of Vascular Smooth Muscle Cells and Mesenchymal Stem Cells by Mechanical Strain

by Kyle Kurpinski¹, Jennifer Park¹, Rahul G. Thakar¹, Song Li¹

1 Department of Bioengineering, University of California at Berkeley
2 Joint Graduate Program in Bioengineering, UC Berkeley and UC San Francisco
3 These authors contributed equally to this work

Molecular & Cellular Biomechanics 2006, 3(1), 21-34. https://doi.org/10.3970/mcb.2006.003.021

Abstract

Vascular smooth muscle cells (SMCs) populate in the media of the blood vessel, and play an important role in the control of vasoactivity and the remodeling of the vessel wall. Blood vessels are constantly subjected to hemodynamic stresses, and the pulsatile nature of the blood flow results in a cyclic mechanical strain in the vessel walls. Accumulating evidence in the past two decades indicates that mechanical strain regulates vascular SMC phenotype, function and matrix remodeling. Bone marrow mesenchymal stem cell (MSC) is a potential cell source for vascular regeneration therapy, and may be used to generate SMCs to construct tissue-engineered vascular grafts for blood vessel replacements. In this review, we will focus on the effects of mechanical strain on SMCs and MSCs, e.g., cell phenotype, cell morphology, cytoskeleton organization, gene expression, signal transduction and receptor activation. We will compare the responses of SMCs and MSCs to equiaxial strain, uniaxial strain and mechanical strain in three-dimensional culture. Understanding the hemodynamic regulation of SMC and MSC functions will provide a basis for the development of new vascular therapies and for the construction of tissue-engineered vascular grafts.

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Keywords

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