Sustained Drug Release from Contact Lenses
J.A.Ferreira; P. Oliveira, P.M. Silva; A. Carreira;
H. Gil and J.N. Murta;


doi:10.3970/cmes.2010.060.151
Source CMES: Computer Modeling in Engineering & Sciences, Vol. 60, No. 2, pp. 151-180, 2010
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Keywords Ophthalmic drug delivery, contact lenses, p-(HEMA/MAA), reaction-diffusion equation, qualitative behavior, in vitro experiments, simulation results.
Abstract This paper focuses on the release of an ophthalmic drug (flurbiprofen) from a loaded copolymer where the drug is simultaneously dispersed in the polymeric matrix and entrapped in particles.
The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. In vitro experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.
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