TY - EJOU
AU - Bartolacelli, Ylenia
AU - Bragantini, Giulia
TI - D-Transposition of the Great Arteries after Arterial Switch Operation: Usefulness of 3D-Echocardiography for Left Ventricle Function Evaluation
T2 - Congenital Heart Disease
PY - 2020
VL - 15
IS - 2
SN - 1747-0803
AB - Objective: The objective of this study was to assess left ventricle (LV)
function and remodeling by three-dimensional echocardiography (3DE) in patients
who underwent arterial switch procedure (ASO) for transposition of great arteries
(TGA) in long-term follow-up. Methods and Results: We studied 54
asymptomatic patients (39 male) who have undergone single-stage ASO for TGA,
aged 13.7 ± 4.7 years, with a normal LV ejection fraction (EF), compared to
healthy peers. We evaluated LV volume and function in asymptomatic patients
with normal ejection fraction by 3DE. All patients had normal EF, measured by
modified Simpson’s method (mean 60.9 ± 3.5%) and by 3D method (mean 62.3 ±
3.8%). No statistically significant differences were documented between 2D and
3D measures of age-related LV volumes. Comparison of 3D volumes with
reference ones was performed only in pediatric patients (<18 years old). In this
subgroup (n = 42) 3D volumes were significantly higher than reference values
from the age of 9 years (End-diastolic volume: 9–12 years 79.61 ± 20.29 ml vs.
53.52 ± 13.94 ml, p < 0.001; 13–17 years 107.30 ± 23.28 ml vs. 81.78 ± 26.44 ml,
p = 0.0038). Conclusions: Children and young adults late after ASO demonstrate
normal ejection fraction, but present subclinical signs of ventricular and
myocardial remodeling, such as increased LV dimensions, when using 3D
echocardiography. Our findings support the usefulness of 3DE to detect LV
remodeling precociously.
KW - Echocardiography; congenital heart disease; 3D echocardiography; transposition of great arteries; arterial switch operation
DO - 10.32604/CHD.2020.011448