Open Access
ARTICLE
Meta-Analysis of the Relationship between Normal Tension Glaucoma, Open-Angle Glaucoma, and Fractional Pressure Reserve
Qi Li1,2, Ningli Wang3, Zhicheng Liu1,2, Lin Li1,2, Zhicheng Liu1,2, Wenjia Wang1,2, Xiaoxue Long1,2, Hongfang Song1,2,*
1 School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China
2 Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing,
100069, China
3 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China
* Corresponding Author: Hongfang Song. Email:
Molecular & Cellular Biomechanics 2020, 17(3), 119-137. https://doi.org/10.32604/mcb.2020.09529
Received 26 December 2019; Accepted 06 March 2020; Issue published 01 July 2020
Abstract
Aim: To investigate the relationship between glaucoma and intraocular
pressure (IOP), intracranial pressure (ICP), trans-laminar cribrosa pressure difference (TLCPD), and the newly proposed fractional pressure reserve (FPR). Methods: Ten articles were analyzed by meta-analysis, and subgroup analysis of three
factors was conducted. Results: The patients with normal tension glaucoma
(NTG) and open-angle glaucoma (OAG) have higher TLCPD and lower ICP than
healthy subjects, with obvious heterogeneity. The greater heterogeneity may arise
from different ICP measurements and from different countries or regions. FPR
performs better than TLCPD in some ways. Conclusion: Both FPR and TLCPD
can be used as indicators of NTG and OAG, and FPR is more effective than
TLCPD in comparisons between different experiments or individuals.
Keywords
Cite This Article
Li, Q., Wang, N., Liu, Z., Li, L., Liu, Z. et al. (2020). Meta-Analysis of the Relationship between Normal Tension Glaucoma, Open-Angle Glaucoma, and Fractional Pressure Reserve.
Molecular & Cellular Biomechanics, 17(3), 119–137.