Open Access
ARTICLE
A Patient-Specific Computational Fluid Dynamic Model of Middle Cerebral Artery Aneurysm Before and One Year After Surgery
Shicheng He1, Juhui Qiu1, Wanling Liu1, Tieying Yin1, Dechuan Zhang2,*, Donghua Liao3,4, Haijun Zhang5, Yuxia Yin5, Guixue Wang1,*
1 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory
for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China
2 Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China
3 GIOME Academia, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
4 Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark
5 National United Engineering Laboratory for Biomedical Material Modification, Dezhou, 251100, China
* Corresponding Authors: Dechuan Zhang. Email: ; Guixue Wang. Email:
Molecular & Cellular Biomechanics 2020, 17(2), 63-74. https://doi.org/10.32604/mcb.2020.08750
Received 04 October 2019; Accepted 23 December 2019;
Abstract
Computational fluid dynamics (CFD) has been widely used for studying intracranial aneurysm hemodynamics, while its use for guiding clinical strategy is still in development. In this study, CFD simulations helped inform
treatment decision for a middle cerebral artery (MCA) aneurysm case was investigated. A patient with a 10.4 × 9.8 mm aneurysm attached with a small aneurysm
at the edge of the trifurcation in the left MCA was included in this study. For
removing the MCA aneurysm, two scenarios were considered: Plan-A involved
clipping the small aneurysm and Plan-B involved clipping the whole aneurysm.
A suitable treatment plan was decided by comparing the clinical measurements
and CFD analysis between these two plans. One-year after the surgery, the
CFD analysis was conducted again on the post-operative aneurysm model to verify the selected surgical plan in terms of morphometric and hemodynamic properties changes in the aneurysm. Based on the CFD simulation and clinical
experience, surgical Plan-A was adopted. One-year after the surgery, both the
hemodynamic and morphological properties improved in the post-operative
aneurysm model, indicating the recovery of the patient. The patient-specific
aneurysm CFD analysis can help to determine a better surgical plan for patients
with special cerebral aneurysms. This study showed how CFD analysis can be
used to aid clinical diagnosis and treatment.
Keywords
Cite This Article
He, S., Qiu, J., Liu, W., Yin, T., Zhang, D. et al. (2020). A Patient-Specific Computational Fluid Dynamic Model of Middle Cerebral Artery Aneurysm Before and One Year After Surgery.
Molecular & Cellular Biomechanics, 17(2), 63–74. https://doi.org/10.32604/mcb.2020.08750